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Table 5 Clinical outcomes of SRS/FSRT for local persistent NPC in the literature

From: Fractionated stereotactic radiotherapy for 136 patients with locally residual nasopharyngeal carcinoma

Author

Number of cases

Modalities

Dose

Results

Major complications

Chang et al. (1999)[29]

23 (P)

SRS

7-15 Gy

2-y LC 100%

no

Tate et al. (1999)[30]

23 (P)

SRS

7-15 Gy

2-y LC 100%

no

Ahn et al. (2000)[31]

19 (B)

FSRT

8-40 Gy/4-20 f

4-yr LC 89%

LMN 1 (5.3%)

4-yr OS 75%

Xiao et al. (2001)[32]

32 (P)

FSRT

14-24 Gy/2-4 f

3-y DFS 74%

FNH 2 (6%)

3-yr OS 70%

Le et al. (2003)[19]

45 (P)

SRS

7-15 Gy

3-y LC 100%

CNI 4 (8.9%)

3-y OS 75%

TLN 3 (6.7%)

Chua et al. (2003)[33]

7 (P)

SRS

11-14 Gy

2-y LC 100%

no

Wu et al. (2007)[20]

34 (P)

FSRT

18 Gy/3 f

3-y LC 89.4%

TLN 3 (8.8%)

3-y DFS 80.7%

Hara et al.[33] (2008)

82 (B)

SRS

7-15 Gy

5-y OS 69%

TLN 10 (12.2%)

Present study

136 (P)

FSRT

8-32 Gy/2-8 f

5-y DFS 73.6%

CNI 8 (5.9%)

5-y OS 76.2%

TLN 6 (4.4%)

     

FNH 5 (3.7%)

  1. P persistent lesions, B boost, LMN local mucosal necrosis, FNH fetal nasopharyngeal hemorrhage, CNI cranial nerve injury, TLN temporal lobe necrosis.