Table 4 Published HRr series with local control and toxicity data
Series | N (patients/metastases) | Lesion size(median) | Fractionation | Local control | Reported toxicity |
|---|---|---|---|---|---|
Aoki et al. [[7]] | 44/65 | - | 5-6 Gy x 3-5 | 72% at 1 year | 2% grade 3 |
Aoyama et al. [[8]] | 87/159 | 3.3 cc | 8.75 Gy x 4 | 81% at 1 year | 7% grade 3 |
DePotter et al. [[9]] | 35/58 | 8.6 cc | WBRT + 6 Gy x 5 | 66% at 1 year | 11% grade 3 |
Fahrig et al. [[17]] | 150/228 | 6.1 cc | 6-7 Gy x 5 | - | 22% |
5 Gy x 7 | - | 7% | |||
10 Gy x 4 | - | 0% | |||
Giubilei et al. [[10]] | 30/44 | 2.1 cm/4.8 cc | 6 Gy x 3/ 8 Gy x 4 | 86% at 1 year | - |
Kwon et al. [[11]] | 27/52 | 1.2 cm/0.5 cc | 20-35 Gy in 4-6 | 68% at 1 year | 5.8% radiation necrosis |
Lindvall et al. [[12]] | 47/47 | - | 8 Gy x 5 | 84% crude | 6.25% radiation necrosis, 1 patient death |
Narayana et al. [[13]] | 20/20 | - | 6 Gy x 5 | 70% at 1 year | 15% |
Ogura et al. [[14]] | 39/46 | 1.8 cm | 7 Gy x 5 or | 17% at 1 year | 2.5% grade 3 |
WBRT + 4-5 Gyx5 | |||||
Wang et al. [[15]] | 37/37 | cavity > 3 cm | 8 Gy x 3 | 80% at 6 months | 9% |
Current Study | 42/42 | 3.9 cm/13.6 cc | 5-8 Gy x 3-5 | 62% at 1 year | 7% radiation necrosis |