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Table 2 Characteristics of loco-regional recurrence of breast cancer and subsequent treatment

From: Radiation dose escalation for loco-regional recurrence of breast cancer after mastectomy

   Dose (Gy)  
  All patients <66 ≥66  
Median time to recurrence (mos) 26 23.5 32.0 NS
Range 2–303 5–241 2–303  
Recurrence site n % N % n %  
 Axilla alone 12 7.5% 7 10.8% 5 5.3% NS
 Reconstructed breast/CW alone 100 62.9% 39 60.0% 61 64.9%  
 SCV alone 12 7.5% 6 9.2% 6 6.4%  
 ICV alone 2 1.3% 1 1.5% 1 1.1%  
 IMC alone 1 0.6% 1 1.5% 0 0.0%  
 Sternum alone 1 0.6% 0 0.0% 1 1.1%  
 Reconstructed breast/CW and lymph nodes 23 14.5% 8 12.3% 15 16.0%  
 Multiple nodal sites 8 5.0% 3 4.6% 5 5.3%  
Multiple sites of recurrence        
 Yes 31 19.5% 11 16.9% 20 21.3% NS
 No 128 80.5% 54 83.1% 74 78.7%  
Systemic therapy for recurrence        
Hormones alone 34 21.4% 13 20.0% 21 22.3% NS
Chemotherapy +/- hormones 111 69.8% 45 69.2% 66 70.2%  
None 12 7.5% 6 9.2% 6 6.4%  
Unknown 2 1.3% 1 1.5% 1 1.1%  
Surgery for recurrence        
 Yes 118 74.2% 51 78.5% 67 71.3% NS
 No 41 25.8% 14 21.5% 27 28.7%  
Gross tumor at time of radiation        
 Yes 42 26.4% 20 30.3% 22 26.4% NS
 No 117 73.6% 45 69.2% 72 73.6%  
   SD   SD   SD  
Median dose (Gy) 63.5 4.4 60.0 3.6 66.0 2.0  
Median microscopic dose (Gy) 51.2 2.6 50.0 2.3 52.3 2.3  
Median boost dose (Gy) 12.9 3.2 10.0 2.2 14.0 3.1  
  1. Recurrent disease and its treatment was similar in both escalated (≥66) and standard (<66) dose groups.