Table 2 Characteristics of loco-regional recurrence of breast cancer and subsequent treatment
From: Radiation dose escalation for loco-regional recurrence of breast cancer after mastectomy
Dose (Gy) | |||||||
|---|---|---|---|---|---|---|---|
All patients | <66 | ≥66 | |||||
Median time to recurrence (mos) | 26 | 23.5 | 32.0 | NS | |||
Range | 2–303 | 5–241 | 2–303 | ||||
Recurrence site | n | % | N | % | n | % | |
Axilla alone | 12 | 7.5% | 7 | 10.8% | 5 | 5.3% | NS |
Reconstructed breast/CW alone | 100 | 62.9% | 39 | 60.0% | 61 | 64.9% | |
SCV alone | 12 | 7.5% | 6 | 9.2% | 6 | 6.4% | |
ICV alone | 2 | 1.3% | 1 | 1.5% | 1 | 1.1% | |
IMC alone | 1 | 0.6% | 1 | 1.5% | 0 | 0.0% | |
Sternum alone | 1 | 0.6% | 0 | 0.0% | 1 | 1.1% | |
Reconstructed breast/CW and lymph nodes | 23 | 14.5% | 8 | 12.3% | 15 | 16.0% | |
Multiple nodal sites | 8 | 5.0% | 3 | 4.6% | 5 | 5.3% | |
Multiple sites of recurrence | |||||||
Yes | 31 | 19.5% | 11 | 16.9% | 20 | 21.3% | NS |
No | 128 | 80.5% | 54 | 83.1% | 74 | 78.7% | |
Systemic therapy for recurrence | |||||||
Hormones alone | 34 | 21.4% | 13 | 20.0% | 21 | 22.3% | NS |
Chemotherapy +/- hormones | 111 | 69.8% | 45 | 69.2% | 66 | 70.2% | |
None | 12 | 7.5% | 6 | 9.2% | 6 | 6.4% | |
Unknown | 2 | 1.3% | 1 | 1.5% | 1 | 1.1% | |
Surgery for recurrence | |||||||
Yes | 118 | 74.2% | 51 | 78.5% | 67 | 71.3% | NS |
No | 41 | 25.8% | 14 | 21.5% | 27 | 28.7% | |
Gross tumor at time of radiation | |||||||
Yes | 42 | 26.4% | 20 | 30.3% | 22 | 26.4% | NS |
No | 117 | 73.6% | 45 | 69.2% | 72 | 73.6% | |
SD | SD | SD | |||||
Median dose (Gy) | 63.5 | 4.4 | 60.0 | 3.6 | 66.0 | 2.0 | |
Median microscopic dose (Gy) | 51.2 | 2.6 | 50.0 | 2.3 | 52.3 | 2.3 | |
Median boost dose (Gy) | 12.9 | 3.2 | 10.0 | 2.2 | 14.0 | 3.1 | |