Skip to main content

Table 1 Allele frequencies of the assessed polymorphisms in 155 Head and Neck cancer patients who either developed minimal (controls: G0-2) or severe (cases: G3-4) late reactions (fibrosis) after radiotherapy

From: RETRACTED ARTICLE: SNPs in genes implicated in radiation response are associated with radiotoxicity and evoke roles as predictive and prognostic biomarkers

Gene and SNP

Allele 1a

Allele 2b

Odds ratio

P-value

 

Cases

Controls

Cases

Controls

(95% CI)

 
 

n (%)

n (%)

n (%)

n (%)

  

CDKN1A C/A rs1801270

74 (77)

157 (73)

22 (23)

57 (27)

0.82 (0.47–1.44)

0.49

TP53 G/C rs1042522

52 (54)

112 (52)

44 (46)

102 (48)

0.93 (0.57–1.51)

0.76

TP53 C/T rs1800371

96 (100)

213 (99.5)

0 (0)

1 (0.5)

NI

NI

ATM G/A rs1801516

82 (85)

202 (94)

14 (15)

12 (6)

2.86 (1.18–6.48)

<0.01

HDM2 T/G rs2279744

71 (74)

125 (58)

25 (26)

89 (42)

0.49 (0.29–0.84)

<0.01

HDM2 T/A rs1196333

95 (99)

198 (93)

1 (1)

16 (7)

0.13 (0.02–0.99)

0.02

TGFB1 G/A rs9282871

95 (99)

213 (99.5)

1 (1)

1 (0.5)

NI

NI

TGFB1 C/T rs1982073

40 (42)

102 (48)

56 (58)

112 (52)

1.28 (0.78–2.07)

0.32

TGFB1 G/C rs1800471

92 (96)

207 (97)

4 (4)

7 (3)

NI

NI

TGFB1 C/T rs1800469

67 (70)

122 (57)

29 (30)

92 (43)

0.57 (0.34–0.96)

0.03

TGFB1 G/A rs11466314

96 (100)

213 (99.5)

0 (0)

1 (0.5)

NI

NI

TGFB1 del rs8179182

94 (98)

214 (100)

2 (2)

0 (0)

NI

NI

TGFB1 C/T rs1800472

92 (96)

199 (93)

4 (4)

15 (7)

0.58 (0.19–1.79)

0.33

TGFB1 C/T rs11466334

95 (99)

213 (99.5)

1 (1)

1 (0.5)

NI

NI

XRCC1 G/A rs25487

83 (86)

155 (72)

13 (14)

59 (28)

0.41 (0.21–0.79)

<0.01

XRCC1 C/T rs3213368

87 (91)

193 (90)

9 (9)

21 (10)

0.95 (0.42–2.16)

0.90

XRCC1 G/A rs2139720

88 (92)

190 (89)

8 (8)

24 (11)

0.72 (0.31–1.67)

0.44

XRCC1 C/T rs3213369

96 (100)

213 (99.5)

0 (0)

1 (0.5)

NI

NI

XRCC3 G/A rs861539

55 (57)

133 (62)

41 (43)

81 (38)

1.22 (0.75–1.99)

0.42

XRCC3 A/C rs3212112

95 (99)

213 (99.5)

1 (1)

1 (0.5)

NI

NI

XRCC4 G/T rs3734091

95 (99)

213 (99.5)

1 (1)

1 (0.5)

NI

NI

XRCC5 A/G rs41296835

96 (100)

213 (99.5)

0 (0)

1 (0.5)

NI

NI

XRCC5 T/C rs1051677

89 (93)

178 (83)

7 (7)

36 (17)

0.39 (0.17–0.91)

0.02

XRCC5 A/G rs1051685

85 (89)

195 (91)

11 (11)

19 (9)

1.33 (0.61–2.91)

0.48

PRKDC T/C rs7830743

93 (97)

197 (92)

3 (3)

17 (8)

0.37 (0.11–1.31)

0.11

LIG4 T/C rs1805384

90 (94)

200 (93)

6 (6)

14 (7)

0.95 (0.36–2.56)

0.92

LIG4 C/T rs4987182

93 (97)

209 (98)

3 (3)

5 (2)

NI

NI

LIG4 C/T rs1805389

95 (99)

206 (96)

1 (1)

8 (4)

NI

NI

LIG4 C/T rs1805388

91 (95)

195 (91)

5 (5)

19 (9)

0.56 (0.20–1.56)

0.26

  1. Significantly associated SNPs are highlighted in bold.
  2. a Allele 1: majority or wild-type allele. b Allele 2: minority or variant allele. NI: Not Informative because of low frequency.