|
Characteristics
|
Pre-Trastuzumab Era
|
Trastuzumab Era
|
p-
value
|
|---|
| |
n = 128
|
n = 441
| |
|
Age (years)
|
0.017
|
|
<65
|
104 (81%)
|
345 (78%)
|
|
≥ 65
|
24 (19%)
|
96 (22%)
|
|
Median
|
53 (26–81)
|
55 (29–91)
|
|
M1 at diagnosis
|
<0.001
|
|
Yes
|
5 (4%)
|
113 (26%)
|
|
No
|
115 (90%)
|
256 (58%)
|
|
Unknown
|
8 (6%)
|
72 (16%)
|
|
Tumor grade
|
0.084
|
|
1
|
0 (0%)
|
13 (3%)
|
|
2
|
24 (19%)
|
106 (24%)
|
|
3
|
95 (74%)
|
315 (71%)
|
|
Unknown
|
9 (7%)
|
7 (2%)
|
|
Hormone receptor status
|
0.83
|
|
ER+
|
51 (40%)
|
180 (41%)
|
|
ER-
|
68 (53%)
|
249 (57%)
|
|
Unknown
|
9 (7%)
|
12 (3%)
|
|
HER2 status
|
<0.001
|
|
Positive
|
33 (26%)
|
176 (40%)
|
|
Negative
|
87 (68%)
|
212 (48%)
|
|
Unknown
|
8 (6%)
|
53 (12%)
|
|
Time from diagnosis to BM (years)
| |
|
Median
|
3.3
|
2.3
| |
|
KPS at BM
|
0.76
|
|
<70
|
47 (37%)
|
170 (38%)
|
|
≥70
|
81 (63%)
|
271 (62%)
|
|
Number of BM
|
0.025
|
|
1
|
44 (34%)
|
117 (27%)
|
|
2-3
|
23 (18%)
|
73 (16%)
|
|
Multiple
|
61 (48%)
|
251 (57%)
|
|
Primary disease at BM
|
0.007
|
|
Controlled
|
104 (81%)
|
305 (70%)
|
|
Uncontrolled
|
24 (19%)
|
135 (31%)
|
|
Extracranial disease at BM
|
0.32
|
|
Brain only
|
22 (17%)
|
97 (22%)
|
|
Bone + brain
|
22 (17%)
|
76 (17%)
|
|
Visceral + brain +/−bone
|
76 (59%)
|
245 (57%)
|
|
Other
|
8 (6%)
|
23 (5%)
|
|
RPA at BM
|
0.17
|
|
1
|
9 (7%)
|
55 (12%)
|
|
2
|
72 (56%)
|
219 (50%)
|
|
3
|
47 (37%)
|
167 (39%)
|
|
Craniotomy
|
0.037
|
|
Yes
|
15 (12%)
|
87 (20%)
|
|
No
|
113 (88%)
|
354 (80%)
|
|
Trastuzumab at BM*
| |
|
Yes
|
0 (0%)
|
150 (34%)
| |
|
No
|
128 (100%)
|
26 (5%)
| |
|
Hormonal therapy at BM*
|
<0.001
|
|
Yes
|
72 (56%)
|
100 (23%)
|
|
No
|
56 (44%)
|
341 (77%)
|
|
Chemotherapy at BM*
|
0.032
|
|
Yes
|
43 (34%)
|
194 (44%)
|
|
No
|
85 (66%)
|
242 (55%)
|
|
Unknown
|
0 (0%)
|
5 (1%)
|
- * Refers to treatments given on or after the date of first brain metastases.
- Abbreviations: ER = estrogen receptor, HER2 = human epidermal growth factor receptor 2, KPS = Karnofsky performance status, BM = brain metastasis, RPA = recursive partitioning analysis.
