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Table 1 Patients’ characteristics

From: Patterns of failure in patients with locally advanced rectal cancer receiving pre-operative or post-operative chemoradiotherapy

  Pre-op CRT (n = 550) Post-op CRT (n = 322) P
Age (mean, yr) 57.0 ± 10.9 57.8 ± 10.5 0.272
Gender    
Male 370 (67.3) 202 (62.7) 0.173
Female 180 (32.7) 120 (37.3)  
Histological grade*    
Low 516 (94.9) 278 (94.9) 0.986
High 28 (5.1) 15 (5.1)  
CEA (ng/mL)    
≤ 5.0 370 (67.3) 178 (65.0) 0.508
> 5.0 180 (32.7) 96 (35.0)  
Tumor location (cm)    
Low (< 5.0) 203 (36.9) 45 (14.9) < 0.001
Middle (5.0–9.0) 347 (63.1) 143 (47.2)  
Upper (> 9.0–12.0)   115 (38.0)  
Clinical stage    
II 111 (20.2) 77 (23.9) 0.196
III 439 (79.8) 245 (76.1)  
Pathological stage    
0 84 (15.3)   < 0.001
I 145 (26.4)   
II 154 (28.0) 88 (27.3)  
III 167 (30.4) 234 (72.7)  
CRM    
Negative 506 (92.0) 290 (90.1) 0.328
Positive 44 (8.0) 32 (9.9)  
  1. Abbreviations: CRT = chemoradiotherapy; CEA = carcinoembryonic antigen; CRM = circumferential resection margin.
  2. *Evaluated with pretreatment diagnostic biopsy specimen. Low = well or moderately differentiated; high = poorly differentiated, mucinous, or signet ring cell carcinoma.
  3. Distance of distal end of tumor from anal verge.
  4. t- test, Chi-square test, or Fisher’s exact test.