| |
Pre-op CRT (n = 550)
|
Post-op CRT (n = 322)
|
P
‡
|
|---|
|
Age (mean, yr)
|
57.0 ± 10.9
|
57.8 ± 10.5
|
0.272
|
|
Gender
| | | |
|
Male
|
370 (67.3)
|
202 (62.7)
|
0.173
|
|
Female
|
180 (32.7)
|
120 (37.3)
| |
|
Histological grade*
| | | |
|
Low
|
516 (94.9)
|
278 (94.9)
|
0.986
|
|
High
|
28 (5.1)
|
15 (5.1)
| |
|
CEA (ng/mL)
| | | |
|
≤ 5.0
|
370 (67.3)
|
178 (65.0)
|
0.508
|
|
> 5.0
|
180 (32.7)
|
96 (35.0)
| |
|
Tumor location (cm) †
| | | |
|
Low (< 5.0)
|
203 (36.9)
|
45 (14.9)
|
< 0.001
|
|
Middle (5.0–9.0)
|
347 (63.1)
|
143 (47.2)
| |
|
Upper (> 9.0–12.0)
| |
115 (38.0)
| |
|
Clinical stage
| | | |
|
II
|
111 (20.2)
|
77 (23.9)
|
0.196
|
|
III
|
439 (79.8)
|
245 (76.1)
| |
|
Pathological stage
| | | |
|
0
|
84 (15.3)
| |
< 0.001
|
|
I
|
145 (26.4)
| | |
|
II
|
154 (28.0)
|
88 (27.3)
| |
|
III
|
167 (30.4)
|
234 (72.7)
| |
|
CRM
| | | |
|
Negative
|
506 (92.0)
|
290 (90.1)
|
0.328
|
|
Positive
|
44 (8.0)
|
32 (9.9)
| |
- Abbreviations: CRT = chemoradiotherapy; CEA = carcinoembryonic antigen; CRM = circumferential resection margin.
- *Evaluated with pretreatment diagnostic biopsy specimen. Low = well or moderately differentiated; high = poorly differentiated, mucinous, or signet ring cell carcinoma.
- †Distance of distal end of tumor from anal verge.
- ‡t- test, Chi-square test, or Fisher’s exact test.
