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Table 1 Patients’ characteristics

From: Patterns of failure in patients with locally advanced rectal cancer receiving pre-operative or post-operative chemoradiotherapy

 

Pre-op CRT (n = 550)

Post-op CRT (n = 322)

P

Age (mean, yr)

57.0 ± 10.9

57.8 ± 10.5

0.272

Gender

   

Male

370 (67.3)

202 (62.7)

0.173

Female

180 (32.7)

120 (37.3)

 

Histological grade*

   

Low

516 (94.9)

278 (94.9)

0.986

High

28 (5.1)

15 (5.1)

 

CEA (ng/mL)

   

≤ 5.0

370 (67.3)

178 (65.0)

0.508

> 5.0

180 (32.7)

96 (35.0)

 

Tumor location (cm)

   

Low (< 5.0)

203 (36.9)

45 (14.9)

< 0.001

Middle (5.0–9.0)

347 (63.1)

143 (47.2)

 

Upper (> 9.0–12.0)

 

115 (38.0)

 

Clinical stage

   

II

111 (20.2)

77 (23.9)

0.196

III

439 (79.8)

245 (76.1)

 

Pathological stage

   

0

84 (15.3)

 

< 0.001

I

145 (26.4)

  

II

154 (28.0)

88 (27.3)

 

III

167 (30.4)

234 (72.7)

 

CRM

   

Negative

506 (92.0)

290 (90.1)

0.328

Positive

44 (8.0)

32 (9.9)

 
  1. Abbreviations: CRT = chemoradiotherapy; CEA = carcinoembryonic antigen; CRM = circumferential resection margin.
  2. *Evaluated with pretreatment diagnostic biopsy specimen. Low = well or moderately differentiated; high = poorly differentiated, mucinous, or signet ring cell carcinoma.
  3. Distance of distal end of tumor from anal verge.
  4. t- test, Chi-square test, or Fisher’s exact test.