Dosimetric parameter predicting the deterioration of hepatic function after helical tomotherapy in patients with unresectable locally advanced hepatocellular carcinoma

Table 3 Dosimetric parameters in patients with or without an increase in Child-Pugh score ≥ 2

Parameters	Without (n = 40)	With (n = 32)	pvalue (95%CI)	ROC curve
Parameters	Without (n = 40)	With (n = 32)	pvalue (95%CI)	AUC	pvalue
PTV (cm³)	103.8 ± 102.8	227.1 ± 193.5	0.004 (1.002-1.011)	0.741	<0.001
Mean dose of NTNL (Gy)	14.9 ± 4.1	20.2 ± 3.2	<0.001 (1.209-1.708)	0.839	<0.001
V_5Gy	76.6 ± 17.5	91.2 ± 7.6	0.001 (1.040-1.153)	0.765	<0.001
V_10Gy	57.1 ± 19.1	79.2 ± 10.7	<0.001 (1.048-1.140)	0.830	<0.001
*V_15Gy	39.2 ± 14.8	61.3 ± 11.9	<0.001 (1.064-1.180)	0.863	<0.001
V_20Gy	27.1 ± 11.0	44.0 ± 11.8	<0.001 (1.069-1.199)	0.852	<0.001
V_25Gy	19.4 ± 8.6	30.5 ± 10.1	<0.001 (1.062-1.204)	0.804	<0.001
V_30Gy	14.8 ± 7.6	21.6 ± 8.3	0.002 (1.040-1.187)	0.738	0.001
V_35Gy	10.5 ± 6.2	15.4 ± 7.1	0.006 (1.033-1.205)	0.706	0.003
V_40Gy	7.2 ± 5.1	9.9 ± 5.1	0.053 (0.999-1.190)	-	-

Abbreviations: CI confidence interval; ROC receiver operating characteristic; AUC area under curve; PTV planning target volume; NTNL non-target normal liver.
*Significant parameter on multivariate logistic regression analysis.

ISSN: 1748-717X