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Table 3 Dosimetric parameters in patients with or without an increase in Child-Pugh score ≥ 2

From: Dosimetric parameter predicting the deterioration of hepatic function after helical tomotherapy in patients with unresectable locally advanced hepatocellular carcinoma

Parameters Without (n = 40) With (n = 32) pvalue (95%CI) ROC curve
AUC pvalue
PTV (cm3) 103.8 ± 102.8 227.1 ± 193.5 0.004 (1.002-1.011) 0.741 <0.001
Mean dose of NTNL (Gy) 14.9 ± 4.1 20.2 ± 3.2 <0.001 (1.209-1.708) 0.839 <0.001
V5Gy 76.6 ± 17.5 91.2 ± 7.6 0.001 (1.040-1.153) 0.765 <0.001
V10Gy 57.1 ± 19.1 79.2 ± 10.7 <0.001 (1.048-1.140) 0.830 <0.001
*V15Gy 39.2 ± 14.8 61.3 ± 11.9 <0.001 (1.064-1.180) 0.863 <0.001
V20Gy 27.1 ± 11.0 44.0 ± 11.8 <0.001 (1.069-1.199) 0.852 <0.001
V25Gy 19.4 ± 8.6 30.5 ± 10.1 <0.001 (1.062-1.204) 0.804 <0.001
V30Gy 14.8 ± 7.6 21.6 ± 8.3 0.002 (1.040-1.187) 0.738 0.001
V35Gy 10.5 ± 6.2 15.4 ± 7.1 0.006 (1.033-1.205) 0.706 0.003
V40Gy 7.2 ± 5.1 9.9 ± 5.1 0.053 (0.999-1.190) - -
  1. Abbreviations: CI confidence interval; ROC receiver operating characteristic; AUC area under curve; PTV planning target volume; NTNL non-target normal liver.
  2. *Significant parameter on multivariate logistic regression analysis.
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Radiation Oncology

ISSN: 1748-717X

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