Skip to main content

Table 4 Univariate analysis for post-RT decompressive surgery

From: Clinical outcomes of radiotherapy as initial local therapy for Graves’ ophthalmopathy and predictors of the need for post-radiotherapy decompressive surgery

Characteristic

Odds ratio

95% CI

p-value

Age*

0.97

0.9 – 1.02

0.20

Sex (F vs. M)

0.8

0.3 – 2.6

0.71

Duration of symptoms prior to RT

   

  ≤ 6 months

reference

  

  6 – 18 months

0.79

0.3 – 2.5

0.69

  > 18 months

1.08

0.3 – 4.2

0.92

Total score at diagnosis

   

  (≥ 6 vs. < 6)

2.71

0.9 – 7.9

0.07

Disease severity

   

  Mild

reference

  

  Moderate

2.78

0.7 – 10.6

0.14

  Severe

3.33

0.4 – 25.4

0.25

Prior surgery

3.89

0.2 – 65.2

0.35

Prior steroid use

1.24

0.5 – 3.4

0.68

Response to prior steroids

   

  (PR vs. none)

0.84

0.2 – 4 0

83

Steroids at initiation of RT

1.17

0.4 – 3.3

0.77

Current smoking

3.6

1.3 – 10.3

0.02#

Total score at 1 month

   

  (> 4 vs. ≤ 4)

3.03

1.04 – 8.9

0.04#

Total score at 4 months*

1.65

1.2 – 2.3

0.003#

Symptoms at diagnosis:

   

  Soft tissue

0.63

0.2 – 1.7

0.37

  Proptosis

1.15

0.4 – 3.6

0.81

  EOM dysfunction

0.62

0.2 – 1.7

0.35

  Objective vision loss

1.59

0.6 – 4.4

0.37

  Diplopia

2.63

0.6 – 12.5

0.23

Symptoms at 4 months:

   

  Soft tissue

1.22

0.4 – 3.5

0.70

  Proptosis

2.12

0.6 – 7.1

0.22

  EOM dysfunction

2

0.7 – 5.7

0.19

  Objective vision loss

4.45

1.5 – 12.9

0.01#

  Diplopia

1.03

0.4 – 2.9

0.96

  1. * denotes continuous variable, # denotes statistical significance.
  2. RT = radiation therapy, CI = confidence interval, F = female, M = male,
  3. PR = partial response, EOM = extraocular eye muscle.