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Table 4 Univariate analysis for post-RT decompressive surgery

From: Clinical outcomes of radiotherapy as initial local therapy for Graves’ ophthalmopathy and predictors of the need for post-radiotherapy decompressive surgery

Characteristic Odds ratio 95% CI p-value
Age* 0.97 0.9 – 1.02 0.20
Sex (F vs. M) 0.8 0.3 – 2.6 0.71
Duration of symptoms prior to RT    
  ≤ 6 months reference   
  6 – 18 months 0.79 0.3 – 2.5 0.69
  > 18 months 1.08 0.3 – 4.2 0.92
Total score at diagnosis    
  (≥ 6 vs. < 6) 2.71 0.9 – 7.9 0.07
Disease severity    
  Mild reference   
  Moderate 2.78 0.7 – 10.6 0.14
  Severe 3.33 0.4 – 25.4 0.25
Prior surgery 3.89 0.2 – 65.2 0.35
Prior steroid use 1.24 0.5 – 3.4 0.68
Response to prior steroids    
  (PR vs. none) 0.84 0.2 – 4 0 83
Steroids at initiation of RT 1.17 0.4 – 3.3 0.77
Current smoking 3.6 1.3 – 10.3 0.02#
Total score at 1 month    
  (> 4 vs. ≤ 4) 3.03 1.04 – 8.9 0.04#
Total score at 4 months* 1.65 1.2 – 2.3 0.003#
Symptoms at diagnosis:    
  Soft tissue 0.63 0.2 – 1.7 0.37
  Proptosis 1.15 0.4 – 3.6 0.81
  EOM dysfunction 0.62 0.2 – 1.7 0.35
  Objective vision loss 1.59 0.6 – 4.4 0.37
  Diplopia 2.63 0.6 – 12.5 0.23
Symptoms at 4 months:    
  Soft tissue 1.22 0.4 – 3.5 0.70
  Proptosis 2.12 0.6 – 7.1 0.22
  EOM dysfunction 2 0.7 – 5.7 0.19
  Objective vision loss 4.45 1.5 – 12.9 0.01#
  Diplopia 1.03 0.4 – 2.9 0.96
  1. * denotes continuous variable, # denotes statistical significance.
  2. RT = radiation therapy, CI = confidence interval, F = female, M = male,
  3. PR = partial response, EOM = extraocular eye muscle.