High survivin expression as a risk factor in patients with anal carcinoma treated with concurrent chemoradiotherapy

Table 3 Univariate analysis for prognostic factors influencing 5 year-survival

	OS	p-value	CSS	p-value	DMFS	p-value	LFFS	p-value
	(%)	p-value	(%)	p-value	(%)	p-value	(%)	p-value
Age
≤ 56 years	84	0.17	84	0.75	83	0.47	81	0.46
> 56 years	87		92		88		82
Sex
Male	75	0.41	80	0.30	80	0.20	72	0.08
Female	93		93		89		89
HIV-status
Positive	73	0.27	73	0.07	72	0.08	73	0.13
Negative	90		93		90		84
T-stage
T1/2	93	0.01	93	<0.01	90	0.02	88	0.02
T3/4	67		76		72		64
N-stage
N0	93	<0.01	93	<0.01	90	0.19	100	<0.01
N+	73		78		81		55
Grading
G1/2	91	<0.01	94	0.04	91	0.08	84	0.14
G3	64		64		65		75
Survivin
low*	92	0.09	92	0.29	94	0.04	80	0.56
high**	75		82		74		85

Abbreviations: OS = overall survival; CSS = cancer specific survival; DMFS = distant metastases-free survival; LFFS = local failure-free survival; HIV = human immunodeficiency virus. *Survivin - weighted score ≤ 8; **survivin - weighted score > 8.

ISSN: 1748-717X