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Table 2 EPIC HRQOL Domain Summary Scores for Patients Treated with US-IMRT and S-IMRT

From: Randomized phase II trial of urethral sparing intensity modulated radiation therapy in low-risk prostate cancer: implications for focal therapy

  US-IMRT (mean ± S.D.) S-IMRT (mean ± S.D.) Total Cohort (mean ± S.D.)
EPIC URINARY DOMAIN  
EPIC-Urine* 6wkRT 75.8 ± 19.1 75.5 ± 12.9 75.6 ± 15.6
ChangeEPIC-U6wkRT -11.1 ± 12.8 -6.2 ± 11.9 -8.6 ± 12.2
EPIC-Urine 1mo 79.4 ± 16.9 82.9 ± 12.2 81.1 ± 14.3
Change EPIC-U1mo -7.6 ± 13.8 1.3 ± 12.2 -3.1 ± 13.4
EPIC-Urine 3mo 86.4 ± 12.7 85.5 ± 11.0 85.9 ± 11.5
Change ΔEPIC-U3mo -0.5 ± 11.2 3.9 ± 15.3 1.7 ± 13.2
EPIC-Urine 1yr 90.4 ± 12.2 89.3 ± 9.4 89.9 ± 10.5
Change EPIC-U1yr 3.5 ± 4.7 7.7 ± 10.2 5.6 ±8.0
EPIC-Urine 2yr 94.5 ± 8.1 89.6 ± 10.9 92.1 ± 9.6
Change EPIC-U2yr 7.6 ± 8.8 8.0 ± 10.4 7.8 ± 9.3
EPIC BOWEL DOMAIN  
EPIC-Bowel †† 3mo 95.1 ± 4.5 88.5 ± 14.1 91.8 ± 10.8
Change EPIC-B3mo -1.6 ± 7.2 -3.9 ± 9.6 -2.7 ± 8.3
EPIC-Bowel 1yr 97.4 ± 5.1 89.8 ± 16.27 93.6 ± 12.3
Change EPIC-B1yr 0.8 ± 5.3 -2.6 ± 11.56 -0.9 ± 8.9
EPIC-Bowel 2yr 96.6 ± 4.45 89.6 ± 12.7 93.1 ± 9.9
Change EPIC-B2yr 0.0 ± 3.0 -2.9 ± 10.4 -1.4 ± 7.5
EPIC SEXUAL DOMAIN  
EPIC-Sex § 3mo 49.2 ± 17.1 46.8 ± 29.2 48.0 ± 23.2
Change EPIC-S3mo -3.3 ± 10.8 -0.6 ± 12.8 -2.0 ± 11.5
EPIC-Sex 1yr 43.0 ± 20.1 47.4 ± 25.5 45.2 ± 22.3
Change EPIC-S1yr -9.6 ± 15.5 0.0 ± 13.4 -4.8 ± 14.8
EPIC-Sex 2yr 39.5 ± 21.4 47.9 ± 32.7 43.7 ± 27.0
Change EPIC-S2yr -13.0 ± 21.6 0.5 ± 5.97 -6.3 ± 16.8
EPIC HORMONAL/VITALITY DOMAIN  
EPIC-Hormonal || 3mo 90.4 ± 14.2 92.2 ± 8.9 91.3 ± 11.5
Change EPIC-H3mo 1.0 ± 4.6 1.6 ± 5.4 1.3 ± 4.9
EPIC-Hormonal 1yr 89.3 ± 14.8 93.0 ± 7.6 91.1 ± 11.5
Change EPIC-H1yr 0.0 ± 6.8 2.3 ± 4.8 1.2 ± 5.8
EPIC-Hormonal 2yr 95.3 ± 5.5 95.6 ± 4.9 95.4 ± 5.1
Change EPIC-H1yr 6.0 ± 10.3 5.0 ± 5.6 5.5 ± 8.0
EPIC SATISFACTION DOMAIN  
EPIC-Satisfaction 3mo 96.4 ± 9.5 90.0 ± 13.7 84.4 ± 25.6
Change EPIC-Sat3mo 10.7 ± 19.7 5.0 ± 20.9 8.3 ± 19.5
EPIC-Satisfaction 1yr 92.9 ± 12.2 95.0 ± 11.2 93.8 ± 8.3
Change EPIC-Sat1yr 7.1 ± 12.2 10.0 ±13.7 8.3 ± 12.3
EPIC-Satisfaction 2yr 100 ± 0 95.0 ± 11.2 97.9 ± 12.5
Change EPIC-Sat2yr 14.3 ± 19.7 10.0 ± 13.7 12.5 ± 16.9
  1. *U = urinary; Δ = change from baseline; ††B = bowel; §S = sexual; ||H = hormonal; Sat = satisfaction
  2. A positive number for change reflects an improvement in HRQOL while a negative number for change reflects a decline in HRQOL. No comparisons between S-IMRT and US-IMRT were statistically different to a p-value <0.05.