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Table 3 Randomized clinical trials of hypofractionated whole breast/chest wall radiotherapy

From: Short course radiotherapy with simultaneous integrated boost for stage I-II breast cancer, early toxicities of a randomized clinical trial

Trial Period n Hypofraction schedule SIB Mastectomy Regional nodes IMRT/ IGRT Chemo-therapy Outcome
Hôpital Necker (*)[32] 1982- 230 5.75 Gy x 4 F/ 17 No Yes ? NS Yes =
1984 days
Royal Marsden Hospital[33] 1986- 1410 3 Gy x 13 F/ 5 No No Yes NS No More local relapses
1998 weeks
Royal Marsden Hospital    3.3 Gy x 13 F/ 5 No No Yes NS No =
weeks
Ontario[18] 1993- 1234 2.66 Gy x 16 F/ 3 No No No NS Yes =
1996 weeks
UK Start A[19] 1998- 2236 3 Gy x 13 F/ 5 No Yes Yes NS Yes More local relapses
2002 weeks
UK Start A    3.2 Gy x 13 F/ 5 No Yes Yes NS Yes =
weeks
Lahore[34] 1998- 300 5.4 Gy x 5 F/ 1 No Yes Yes NS Yes =
2004 week
Lahore    3.5 Gy x 10 F/ 2 No Yes Yes NS Yes =
weeks
Lahore    2.66 Gy x 15 F/ 3 No Yes Yes NS Yes Control arm
weeks
UK Start B[20] 1999- 2215 2.67 Gy x 15 F/ 3 No Yes Yes NS Yes =
2001 weeks
Egypt NCI[35] 2002- 30 2.66 Gy x 16 F/ 3 No No No NS No Boost in conventional arm
2003 weeks
UK FAST[36] 2004- 915 5.7 Gy x 5 F/ 5 ? No No Yes No =
2007 weeks
UK FAST    6 Gy x 5 F/ 5 ? No No Yes No More breast toxicity
weeks
DBCG 2009 RT Hypo[37] 2009- 1500** 2.67 Gy x 15 F/ 3 No No No Yes Yes On-going
weeks
UK IMPORT HIGH 2009- 840** 2.4 Gy [SIB 3.2 Gy] Yes No ? Yes ? On-going
x 15 F/
UK IMPORT HIGH    2.4 Gy [SIB 3.53 Gy] Yes No ? Yes ?  
x 15 F/
UZ Brussel 2007- 122 2.8 Gy [SIB 3.4 Gy] Yes Yes Yes Yes Yes Closed for inclusion; FU on-going
[this study] x 15 F/ 3 weeks
  1. (*) Partial report; full study 1982–1989, n = 525 patients. (**) Planned accrual.
  2. NS: not stated. =: outcome comparable with control arm. SIB: simultaneous integrated boost. FU: follow-up.
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Radiation Oncology

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