Short course radiotherapy with simultaneous integrated boost for stage I-II breast cancer, early toxicities of a randomized clinical trial

Hilde Van Parijs; Geertje Miedema; Vincent Vinh-Hung; Sylvia Verbanck; Nele Adriaenssens; Dirk Kerkhove; Truus Reynders; Daniel Schuermans; Katrien Leysen; Shane Hanon; Guy Van Camp; Walter Vincken; Guy Storme; Dirk Verellen; Mark De Ridder

doi:10.1186/1748-717X-7-80

Table 3 Randomized clinical trials of hypofractionated whole breast/chest wall radiotherapy

From: Short course radiotherapy with simultaneous integrated boost for stage I-II breast cancer, early toxicities of a randomized clinical trial

Trial	Period	n	Hypofraction schedule	SIB	Mastectomy	Regional nodes	IMRT/ IGRT	Chemo-therapy	Outcome
Hôpital Necker (*)[32]	1982-	230	5.75 Gy x 4 F/ 17	No	Yes	?	NS	Yes	=
Hôpital Necker (*)[32]	1984	230	days	No	Yes	?	NS	Yes	=
Royal Marsden Hospital[33]	1986-	1410	3 Gy x 13 F/ 5	No	No	Yes	NS	No	More local relapses
Royal Marsden Hospital[33]	1998	1410	weeks	No	No	Yes	NS	No	More local relapses
Royal Marsden Hospital			3.3 Gy x 13 F/ 5	No	No	Yes	NS	No	=
Royal Marsden Hospital			weeks	No	No	Yes	NS	No	=
Ontario[18]	1993-	1234	2.66 Gy x 16 F/ 3	No	No	No	NS	Yes	=
Ontario[18]	1996	1234	weeks	No	No	No	NS	Yes	=
UK Start A[19]	1998-	2236	3 Gy x 13 F/ 5	No	Yes	Yes	NS	Yes	More local relapses
UK Start A[19]	2002	2236	weeks	No	Yes	Yes	NS	Yes	More local relapses
UK Start A			3.2 Gy x 13 F/ 5	No	Yes	Yes	NS	Yes	=
UK Start A			weeks	No	Yes	Yes	NS	Yes	=
Lahore[34]	1998-	300	5.4 Gy x 5 F/ 1	No	Yes	Yes	NS	Yes	=
Lahore[34]	2004	300	week	No	Yes	Yes	NS	Yes	=
Lahore			3.5 Gy x 10 F/ 2	No	Yes	Yes	NS	Yes	=
Lahore			weeks	No	Yes	Yes	NS	Yes	=
Lahore			2.66 Gy x 15 F/ 3	No	Yes	Yes	NS	Yes	Control arm
Lahore			weeks	No	Yes	Yes	NS	Yes	Control arm
UK Start B[20]	1999-	2215	2.67 Gy x 15 F/ 3	No	Yes	Yes	NS	Yes	=
UK Start B[20]	2001	2215	weeks	No	Yes	Yes	NS	Yes	=
Egypt NCI[35]	2002-	30	2.66 Gy x 16 F/ 3	No	No	No	NS	No	Boost in conventional arm
Egypt NCI[35]	2003	30	weeks	No	No	No	NS	No	Boost in conventional arm
UK FAST[36]	2004-	915	5.7 Gy x 5 F/ 5	?	No	No	Yes	No	=
UK FAST[36]	2007	915	weeks	?	No	No	Yes	No	=
UK FAST			6 Gy x 5 F/ 5	?	No	No	Yes	No	More breast toxicity
UK FAST			weeks	?	No	No	Yes	No	More breast toxicity
DBCG 2009 RT Hypo[37]	2009-	1500**	2.67 Gy x 15 F/ 3	No	No	No	Yes	Yes	On-going
DBCG 2009 RT Hypo[37]	2009-	1500**	weeks	No	No	No	Yes	Yes	On-going
UK IMPORT HIGH	2009-	840**	2.4 Gy [SIB 3.2 Gy]	Yes	No	?	Yes	?	On-going
UK IMPORT HIGH	2009-	840**	x 15 F/	Yes	No	?	Yes	?	On-going
UK IMPORT HIGH			2.4 Gy [SIB 3.53 Gy]	Yes	No	?	Yes	?
UK IMPORT HIGH			x 15 F/	Yes	No	?	Yes	?
UZ Brussel	2007-	122	2.8 Gy [SIB 3.4 Gy]	Yes	Yes	Yes	Yes	Yes	Closed for inclusion; FU on-going
[this study]			x 15 F/ 3 weeks

(*) Partial report; full study 1982–1989, n = 525 patients. (**) Planned accrual.
NS: not stated. =: outcome comparable with control arm. SIB: simultaneous integrated boost. FU: follow-up.

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