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Table 3 Univariate analysis correlating prognostic factors with disease control above clavicles

From: Concurrent radiochemotherapy in locally-regionally advanced oropharyngeal squamous cell carcinoma: analysis of treatment results and prognostic factors

Factor   LRFS RRFS LRRFS
n 2 years
%
p-value 2 years
%
p-value 2 years
%
p-value
Gender
 Male 59 45.2 0,2713 52.3 0,0527 36.2 0,1562
 Female 6 83.0   100.0   83.3  
Age (years)
 ≤ 50 20 49.3 0,7046 42.3 0,3524 30.7 0,6735
 > 50 45 48.2   63.2   44.8  
Performance status (ECOG)
 0 44 62.8 0,0004 68.3 0,0169 54.7 0,0004
 1 21 19.2   20.8   9.8  
Cigarette smoking
 Non-smokers 11 77.7 0,1651 89.8 0,0365 79.9 0,0475
 Current smokers 54 43.2   49.8   33.8  
Alcohol consumption
 Non-drinkers 25 71.8 0,0163 75.3 0,0222 64.7 0,0094
 Current drinkers 40 34.8   47.2   27.2  
Subsite
 Tonsil 36 42.8 0,3656 58.7 0,7991 37.8 0.4509
 Base of tongue 21 66.7   54.7   45.9  
 Soft palate 6 49.2   50.2   50.9  
 Posterior pharyngeal wall 2 0   0   0  
T stage
 T2-3 47 54.0 0,1094 58.8 0,9960 49.1 0,0451
 T4 18 35.4   48.1   21.6  
N stage
 N0-1 34 68.8 0.0006 93.8 <0.0001 66.6 <0.0001
 N2-3 31 28.3   22.2   16.4  
Overall stage        
 III 23 81.7 0.0002 95.3 <0.0001 81.6 <0.0001
 IVA-B 42 30.8   33.2   19.1  
Histological differentiation
 Well 22 57.2 0,1931 59.2 0,1385 44.1 0,2296
 Moderate 25 54.3   76.3   54.7  
 Poor 18 31.8   36.3   23.4  
Haemoglobin level
 ≤ 12.5 g/dL 20 21.3 <0.0001 44.2 0,0046 19.0 <0.0001
 > 12.5 g/dL 45 60.1   65.8   51.5  
  1. n, number of patients; LRFS, local relapse-free survival; RRFS, regional relapse-free survival; LRRFS, locoregional relapse-free survival; ECOG, Eastern Cooperative Oncology Group.