Neurocognitive function impairment after whole brain radiotherapy for brain metastases: actual assessment

Radiation Oncology

Table 1 Neurocognitive impairment after WBRT as assessed by MMSE

Study	N	Radiation scheme	Brain control	Assessment time
				% of patients impaired
				2month	3mo	6mo	12mo	18mo
Regine et al., 2001	182	30 Gy/10 fractions/12	Yes	0	0	NR	NR	NR
[16]		days (TCI)	No	28	46
Shibamoto et al., 2008 [17]	92	40 Gy/20 fractions/33 days (TCI)	Yes	NR	7.4	11	12	0
Corn et al., 2008 [18]	92	37.5 Gy/15fractions/19 days (TCI)	Yes	18	24	24	28	28
Corn et al., 2008 [18]	92	37.5 Gy/15fractions/19 days (TCI)	No	23	23	33	38	40
Aoyama et al., 2007 [12]	41	30 Gy/10 fractions/12 days (TCI)	NR	5 ^a	16^a	16 ^a	28 ^a	40 ^a
				2 ^b	10 ^b	14 ^b	21 ^b	21 ^b
				5 ^c	14 ^c	16 ^c	24 ^c	24 ^c
Sun et al., 2011 [19]	340	30 Gy/15 fractions/19 days (PCI)	NR	NR	36	28	23	NR

Only studies from which percentages of patients impaired on NCF could be extracted are reported in this table. WBRT = Whole Brain Radiation Therapy; TCI = Therapeutic Cranial Irradiation; PCI = Prophylactic Cranial Irradiation; NR = not reported; ^a = patients who underwent a 3-point decrease in MMSE; ^b = patients who underwent a decrease of MMSE ≤ 26; ^c = patients who underwent a 3-point decrease in MMSE, excluding those who return to their initial MMSE.

ISSN: 1748-717X