Figure 5
From: Vascular responses to radiotherapy and androgen-deprivation therapy in experimental prostate cancer
Semi-quantitative and pharmacokinetic analysis of dynamic contrast-enhanced MRI. Both semi-quantitative and pharmacokinetic DCE MRI parameters unveiled increased vascularization in androgen-deprived (AD) tumors. Intergroup differences between untreated (Ctrl), irradiated (RT), and androgen-deprived (AD) prostate carcinoma (PC) xenografts for the semi-quantitative parameter area under the relative signal intensity curve ( AUC) (a.u.) for 1 min ( A), 5 min ( B), 10 min ( C), and 20 min ( D), and Tofts kinetic model parameters Ktrans (s-1) (E), k ep (s-1) (F), and V e (a.u.) (G), in addition to the fraction of unfitted voxels (H), summarized as mean and s.e.m. per group. Significant differences (p < 0.05) compared to Ctrl tumors are indicated with a *.