Figure 1
From: Vascular responses to radiotherapy and androgen-deprivation therapy in experimental prostate cancer
Dynamic contrast-enhanced MRI of experimental prostate cancer. Following dynamic contrast-enhanced (DCE) MRI the tumors were traced in the T1-weighted images. Firstly, semi-quantitative analysis was performed on the time-dependent relative signal intensity (RSI(t)) curves, by calculating the area under the RSI curve (AUC(t)), of each tumor voxel, for different time-points. Secondly, pharmacokinetic analysis was performed using the Tofts model, producing parametric tumor maps of Ktrans, k ep , and V e . Examples of parametric tumor maps are shown to the right.