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Figure 5 | Radiation Oncology

Figure 5

From: Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts

Figure 5

Ionizing Radiation (IR) inhibits Akt-mTOR pro-survival pathway in A549 and H1299 lung carcinoma xenografts. ( A) Lysates from Control and IR treated tumours were subjected to immunoblot analysis using Akt, P-Akt (S473), P-Akt (Thr308), mTOR, P-mTOR (Ser2448) and P-4EBP1 antibodies. A representative immunoblot from 6 independent experiments is shown. ( B) The immunoblot densitometric values are shown as percent change in protein expression relative to the control group (*p < 0.05; **p < 0.001).

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