Table 1 SNP characteristics and population
Gene | rs no. | SNP a | Codon/ position | Change inamino acid | Function of gene product | Primers | Relative excess heterozygosity (95% confidence interval) | p-value HWE b | |
|---|---|---|---|---|---|---|---|---|---|
ATM | rs1801516 | G/A | 1853 | Asp > Asn | DNA repair | --- | --- | 0.802 (0.350 – 1.861) | 0.842 |
GSTP1 | rs1695 | A/G | 105 | Val > Isol | ROS pathway | 5′-ACCCCAGGG CTCTATGGGAA-3′ | 5′-TGAGGGCACA AGAAGCCCCT-3′ | 1.104 (0.670 – 1.815) | 0.924 |
SOD2 | rs4880 | C/T | 16 | Ala > Val | ROS pathway | --- | --- | 1.798 (1.130 – 2.849) | 0.037 |
TGFB1 | rs1800469 | C/T | pos.509 | – | Pro-fibrotic cytokine | 5′-CAGACTTCTAGA GACTGTCAG-3′ | 5′-GTCACCAGA GAAAGAGGAC-3′ | 0.993 (0.640 – 1.549) | 0.987 |
XPD | rs13181 | A/C | 751 | Lys > Gln | DNA repair | --- | --- | 1.030 (0.640 – 1.656) | 0.987 |
XRCC1 | rs25487 | G/A | 399 | Arg > Gln | DNA repair | 5′-TTGTGCTTTC TCTGTGTCCA-3′ | 5′-TCCTCCAGCC TTTTCTGATA-3′ | 0.735 (0.460 – 1.164) | 0.424 |