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Table 2 Descriptive statistics of the mean value and its standard deviation as well as the median values prior and after treatment of rhabdoid tumor xenografts with vehicle (DMSO), suberoylanilide hydroxamic acid (SAHA), irradiation (XRT) or XRT and SAHA

From: In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model

Parameter

Control

SAHA

XRT

SAHA + XRT

 

Mean (SD) prior

Mean (SD) after

Mean (SD) prior

Mean (SD) after

Mean (SD) prior

Mean (SD) after

Mean (SD) prior

Mean (SD) after

k1

0.015 (0.04)

0.13 (0.06)

0.16 (0.04)

0.1 (0.01)

0.14 (0.01)

0.16 (0.02)

0.14 (0.01)

0.15 (0.05)

k2

0.32 (0.07)

0.38 (0.02)

0.37 (0.12)

0.24 (0.08)

0.33 (0.03)

0.34 (0.02)

0.39 (0.03)

0.39 (0.02)

k3

0.08 (0.03)

0.11 (0.06)

0.07 (0.04)

0.1 (0.08)

0.06 (0.02)

0.08 (0.02)

0.08 (0.01)

0.09 (0.00)

VB

0.01 (0.001)

0.02 (0.002)

0.03 (0.002)

0.01 (0.001)

0.04 (0.001)

0.01 (0.001)

0.04 (0.003)

0.01 (0.001)

Influx constant Ki (=(k1xk3)/(k2+k3)

0.03

0.03

0.02

0.03

0.02

0.03

0.02

0.03

Max mSUV

1323 (368)

1593 (631)

2341 (1135)

729 (305)

1676 (782)

1578 (1206)

1314 (767)

1158 (816)