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Table 2 Apoptotic rates measured by the sub-G1 portion of flow cytometry in A549 and U373MG cells

From: DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity

  

Control/drug

0 h

2 h

6 h

12 h

24 h

A549

IR

1.11 ± 0.93

1.55 ± 0.82

3.01 ± 1.93

1.72 ± 0.83

1.20 ± 0.99

1.03 ± 0.33

 

PSA + IR

2.61 ± 1.05

1.53 ± 0.73

3.29 ± 1.71

8.02 ± 2.49

9.02 ± 3.20

7.72 ± 2.16

 

IR

0.53 ± 0.10

1.23 ± 1.07

0.98 ± 0.37

0.70 ± 0.06

1.13 ± 0.88

0.89 ± 0.12

 

DAC + IR

0.43 ± 0.10

1.20 ± 0.70

0.54 ± 0.02

0.57 ± 0.09

0.53 ± 0.07

1.05 ± 0.14

 

IR

0.59 ± 0.16

0.94 ± 0.60

0.61 ± 0.15

0.86 ± 0.33

1.77 ± 0.66

1.66 ± 0.14

 

ZEB + IR

0.84 ± 0.32

1.00 ± 0.61

0.97 ± 0.49

1.65 ± 0.52

1.62 ± 0.14

2.13 ± 0.05

U373MG

IR

0.95 ± 0.10

0.61 ± 0.23

0.80 ± 0.18

0.71 ± 0.09

1.39 ± 0.20

1.68 ± 0.55

 

PSA + IR

0.71 ± 0.19

0.67 ± 0.13

0.55 ± 0.06

0.63 ± 0.05

0.89 ± 0.16

1.57 ± 0.61

 

IR

0.94 ± 0.05

0.64 ± 0.13

0.61 ± 0.05

0.64 ± 0.05

0.99 ± 0.20

1.68 ± 0.65

 

DAC + IR

0.77 ± 0.04

0.83 ± 0.01

0.58 ± 0.05

0.81 ± 0.08

0.93 ± 0.12

1.45 ± 0.37

 

IR

1.58 ± 0.25

1.39 ± 0.34

1.35 ± 0.01

1.12 ± 0.21

1.78 ± 0.34

2.33 ± 0.35

 

ZEB + IR

0.95 ± 0.19

1.90 ± 1.21

2.14 ± 1.48

1.06 ± 0.01

1.28 ± 0.15

4.59 ± 1.23

  1. Abbreviations: IR = irradiation, PSA = psammplin A, DAC = 5-aza-2'-deoxycytidine, ZEB = zebularine