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Table 1 IC50 values for six DNMT inhibitors

From: DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity

Drugs

Cell lines

 

A549

U373MG

5-azacytine

3 uM

3 uM

5-aza-2'-deoxycytidine

300 nM

100 nM

Zebularine

800 uM

ND*

Hydralazine

2 uM

20 uM

Epigallocatechin gallate

15 uM

5 uM

Psammaplin A

5 ug/ml

5 ug/ml

  1. *ND; not determined, IC50 value in U373MG, 800 uM, was used in subsequent experiments in A549 cells
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Radiation Oncology

ISSN: 1748-717X

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