Figure 6

Vosaroxin causes a greater than additive increase in tumor growth delay. Mice were implanted with 1 × 10⁶ U251cells on the lateral aspect of the rear leg. Tumors were randomized at 172 mm³ into four groups and treated with either vehicle control, vosaroxin alone (10 mg/kg by tail vein injection), radiotherapy (3 Gy), vosaroxin/3 Gy. Tumors were measured three times per week and followed until they reached at least 1,000 mm³. Volumes were calculated using the formula (L × W × W)/2.