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Figure 2 | Radiation Oncology

Figure 2

From: Radiosensitization by the novel DNA intercalating agent vosaroxin

Figure 2

Vosaroxin enhances radiation sensitivity in tumor cell lines. The effects of vosaroxin on radiosensitivity by clonogenic assay. Cells were seeded as a single-cell suspension with a specified number of cells. After allowing cells time to attach (6 h), vosaroxin or the vehicle control was added at specified concentrations and the plates were irradiated 16 h later. Ten to fourteen days after seeding, survival curves were generated after normalizing for the cytotoxicity generated by vosaroxin alone. Figure shows U251 (A), DU145 (B), MiaPaca-2 (C), and a table showing cytotoxicity of vosaroxin alone and the radiation dose enhancement factor (DEF) for each cell line and drug dose combination (D). Data presented are the mean ± SE from at least three independent experiments.

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