|
CCRT toxicity
|
Arm A (cisplatin 100 mg/m2)
|
Arm B (cisplatin 40 mg/m2)
|
p
|
|---|
|
N = 26
|
N = 24
|
|---|
|
Overall toxicity
|
|
Grade 2
|
5 (19.2%)
|
2 (8.3%)
|
0.020*
|
|
Grade 3
|
21 (80.8%)
|
16 (66.7%)
|
|
Grade 4
|
0 (0%)
|
6 (25.0%)
|
|
Non-hematologic
|
|
Mucositis
|
|
< Grade 3
|
16 (61.5%)
|
6 (25.0%)
|
0.012*
|
|
≥ Grade 3
|
10 (38.5%)
|
18 (75.0%)
|
|
Pharyngitis
|
|
< Grade 3
|
12 (46.2%)
|
11 (45.8%)
|
1.000
|
|
≥ Grade 3
|
14 (53.8%)
|
13 (54.2%)
|
|
Stomatitis
|
|
< Grade 3
|
12 (46.2%)
|
11 (45.8%)
|
1.000
|
|
≥ Grade 3
|
14 (53.8%)
|
13 (54.2%)
|
|
Laryngeal edema
|
|
< Grade 3
|
23 (88.5%)
|
23 (95.8%)
|
0.611
|
|
≥ Grade 3
|
3 (11.5%)
|
1 (4.2%)
|
|
Dermatitis
|
|
< Grade 3
|
24 (92.3%)
|
22 (91.7%)
|
1.000
|
|
≥ Grade 3
|
2 (7.7%)
|
2 (8.3%)
|
|
Nausea/vomiting
|
|
< Grade 3
|
23 (88.5%)
|
19 (79.2%)
|
0.456
|
|
≥ Grade 3
|
3 (11.5%)
|
5 (20.8%)
|
|
Hematologic
|
|
Anemia
|
|
< Grade 3
|
25 (96.2%)
|
23 (95.8%)
|
1.000
|
|
≥ Grade 3
|
1 (3.8%)
|
1 (4.2%)
|
|
Leukopenia
|
|
< Grade 3
|
26 (100%)
|
21 (87.5%)
|
0.103
|
|
≥ Grade 3
|
0 (0%)
|
3 (12.5%)
|
|
Neutropenia
|
|
< Grade 3
|
26 (100%)
|
23 (95.8%)
|
0.480
|
|
≥ Grade 3
|
0 (0%)
|
1 (4.2%)
|
|
Thrombocytopenia
|
|
< Grade 3
|
26 (100%)
|
24 (100%)
|
NS
|
|
≥ Grade 3
|
0 (0%)
|
0 (0%)
|
- Abbreviations: CCRT = concurrent chemoradiotherapy; NS = no statistics were computed.
- * Statistically significant, p < 0.05.
