Table 3 Acute toxicity profile
CCRT toxicity | Arm A (cisplatin 100 mg/m2) | Arm B (cisplatin 40 mg/m2) | p |
|---|---|---|---|
N = 26 | N = 24 | ||
Overall toxicity | |||
Grade 2 | 5 (19.2%) | 2 (8.3%) | 0.020* |
Grade 3 | 21 (80.8%) | 16 (66.7%) | |
Grade 4 | 0 (0%) | 6 (25.0%) | |
Non-hematologic | |||
Mucositis | |||
< Grade 3 | 16 (61.5%) | 6 (25.0%) | 0.012* |
≥ Grade 3 | 10 (38.5%) | 18 (75.0%) | |
Pharyngitis | |||
< Grade 3 | 12 (46.2%) | 11 (45.8%) | 1.000 |
≥ Grade 3 | 14 (53.8%) | 13 (54.2%) | |
Stomatitis | |||
< Grade 3 | 12 (46.2%) | 11 (45.8%) | 1.000 |
≥ Grade 3 | 14 (53.8%) | 13 (54.2%) | |
Laryngeal edema | |||
< Grade 3 | 23 (88.5%) | 23 (95.8%) | 0.611 |
≥ Grade 3 | 3 (11.5%) | 1 (4.2%) | |
Dermatitis | |||
< Grade 3 | 24 (92.3%) | 22 (91.7%) | 1.000 |
≥ Grade 3 | 2 (7.7%) | 2 (8.3%) | |
Nausea/vomiting | |||
< Grade 3 | 23 (88.5%) | 19 (79.2%) | 0.456 |
≥ Grade 3 | 3 (11.5%) | 5 (20.8%) | |
Hematologic | |||
Anemia | |||
< Grade 3 | 25 (96.2%) | 23 (95.8%) | 1.000 |
≥ Grade 3 | 1 (3.8%) | 1 (4.2%) | |
Leukopenia | |||
< Grade 3 | 26 (100%) | 21 (87.5%) | 0.103 |
≥ Grade 3 | 0 (0%) | 3 (12.5%) | |
Neutropenia | |||
< Grade 3 | 26 (100%) | 23 (95.8%) | 0.480 |
≥ Grade 3 | 0 (0%) | 1 (4.2%) | |
Thrombocytopenia | |||
< Grade 3 | 26 (100%) | 24 (100%) | NS |
≥ Grade 3 | 0 (0%) | 0 (0%) | |