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Table 3 Acute toxicity profile
| CCRT toxicity | Arm A (cisplatin 100 mg/m2) | Arm B (cisplatin 40 mg/m2) | p |
|---|---|---|---|
| N = 26 | N = 24 | ||
| Overall toxicity | |||
| Grade 2 | 5 (19.2%) | 2 (8.3%) | 0.020* |
| Grade 3 | 21 (80.8%) | 16 (66.7%) | |
| Grade 4 | 0 (0%) | 6 (25.0%) | |
| Non-hematologic | |||
| Mucositis | |||
| < Grade 3 | 16 (61.5%) | 6 (25.0%) | 0.012* |
| ≥ Grade 3 | 10 (38.5%) | 18 (75.0%) | |
| Pharyngitis | |||
| < Grade 3 | 12 (46.2%) | 11 (45.8%) | 1.000 |
| ≥ Grade 3 | 14 (53.8%) | 13 (54.2%) | |
| Stomatitis | |||
| < Grade 3 | 12 (46.2%) | 11 (45.8%) | 1.000 |
| ≥ Grade 3 | 14 (53.8%) | 13 (54.2%) | |
| Laryngeal edema | |||
| < Grade 3 | 23 (88.5%) | 23 (95.8%) | 0.611 |
| ≥ Grade 3 | 3 (11.5%) | 1 (4.2%) | |
| Dermatitis | |||
| < Grade 3 | 24 (92.3%) | 22 (91.7%) | 1.000 |
| ≥ Grade 3 | 2 (7.7%) | 2 (8.3%) | |
| Nausea/vomiting | |||
| < Grade 3 | 23 (88.5%) | 19 (79.2%) | 0.456 |
| ≥ Grade 3 | 3 (11.5%) | 5 (20.8%) | |
| Hematologic | |||
| Anemia | |||
| < Grade 3 | 25 (96.2%) | 23 (95.8%) | 1.000 |
| ≥ Grade 3 | 1 (3.8%) | 1 (4.2%) | |
| Leukopenia | |||
| < Grade 3 | 26 (100%) | 21 (87.5%) | 0.103 |
| ≥ Grade 3 | 0 (0%) | 3 (12.5%) | |
| Neutropenia | |||
| < Grade 3 | 26 (100%) | 23 (95.8%) | 0.480 |
| ≥ Grade 3 | 0 (0%) | 1 (4.2%) | |
| Thrombocytopenia | |||
| < Grade 3 | 26 (100%) | 24 (100%) | NS |
| ≥ Grade 3 | 0 (0%) | 0 (0%) | |
