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Table 2 OARs dosimetric endpoints of TD-3DCRT, TD-IMRT and FIF techniques for AWBRT

From: Does TomoDirect 3DCRT represent a suitable option for post-operative whole breast irradiation? A hypothesis-generating pilot study

Structure Endpoint Technique Value p
ISPILATERAL LUNG V 5Gy (%) TD-3DCRT 21.6 ± 5.3  
TD-IMRT 18.7 ± 4.2 p < 0.01
FIF 22.4 ± 5.2 NS
V 10Gy (%) TD-3DCRT 16.8 ± 4.6  
TD-IMRT 13.9 ± 3.3 p < 0.01
FIF 15.8 ± 4.2 NS
V 20Gy (%) TD-3DCRT 13.2 ± 4.1  
TD-IMRT 9.9 ± 2.3 p < 0.001
FIF 11.7 ± 3.6 p < 0.05
MLD (Gy) TD-3DCRT 6.9 ± 1.8  
TD-IMRT 5.6 ± 1.1 p < 0.001
FIF 6.3 ± 1.5 NS
V 30Gy (%)* TD-3DCRT 6.5 ± 2.3  
TD-IMRT 6.9 ± 1.5 NS
FIF 7.3 ± 2.2 NS
V 40Gy (%)* TD-3DCRT 5.3 ± 1.8  
TD-IMRT 4.5 ± 1.2 NS
FIF 4.2 ± 1.8 p < 0.05
HEART V 25Gy (%) TD-3DCRT 5.5 ± 4.6  
TD-IMRT 3.4 ± 3.1 p < 0.01
FIF 3.4 ± 3.6 p < 0.01
MHD (Gy) TD-3DCRT 4.0 ± 2.2  
TD-IMRT 3.0 ± 1.4 p < 0.05
FIF 3.0 ± 1.6 p < 0.01
CONTRALATERAL LUNG D 0.1cc (Gy) TD-3DCRT 1.8 ± 0.6  
TD-IMRT 1.5 ± 0.5 p < 0.01
FIF 2.3 ± 0.9 p < 0.001
CONTRALATERAL BREAST D 0.1cc (Gy) TD-3DCRT 3.4 ± 1.9  
TD-IMRT 2.3 ± 1.3 p < 0.05
FIF 4.3 ± 3.0 NS
D mean (Gy) TD-3DCRT 0.43 ± 0.09  
TD-IMRT 0.38 ± 0.07 p < 0.05
FIF 0.52 ± 0.12 p < 0.001
Normal tissues external to PTV D 2cc (%) ^ TD-3DCRT 8.3 ± 2.3  
TD-IMRT 5.0 ± 1.4 p < 0.001
   FIF 4.4 ± 1.3 p < 0.001
  1. Statistically significant differences between TD-3DCRT and the other techniques were considered significant for p < 0.05.
  2. *Volumes of ipsilateral lung receiving 30 Gy and 40 Gy were calculated for TD-3DCRT plan class patients only.
  3. ^as percentage of Rx.
  4. Two-tailed p values from paired Wilcoxon test.
  5. Data presented as mean ± standard devation.