|
Structure
|
Endpoint
|
Technique
|
Value
|
p
|
|---|
|
ISPILATERAL LUNG
|
V
5Gy
(%)
|
TD-3DCRT
|
21.6 ± 5.3
| |
|
TD-IMRT
|
18.7 ± 4.2
|
p < 0.01
|
|
FIF
|
22.4 ± 5.2
|
NS
|
|
V
10Gy
(%)
|
TD-3DCRT
|
16.8 ± 4.6
| |
|
TD-IMRT
|
13.9 ± 3.3
|
p < 0.01
|
|
FIF
|
15.8 ± 4.2
|
NS
|
|
V
20Gy
(%)
|
TD-3DCRT
|
13.2 ± 4.1
| |
|
TD-IMRT
|
9.9 ± 2.3
|
p < 0.001
|
|
FIF
|
11.7 ± 3.6
|
p < 0.05
|
|
MLD (Gy)
|
TD-3DCRT
|
6.9 ± 1.8
| |
|
TD-IMRT
|
5.6 ± 1.1
|
p < 0.001
|
|
FIF
|
6.3 ± 1.5
|
NS
|
|
V
30Gy
(%)*
|
TD-3DCRT
|
6.5 ± 2.3
| |
|
TD-IMRT
|
6.9 ± 1.5
|
NS
|
|
FIF
|
7.3 ± 2.2
|
NS
|
|
V
40Gy
(%)*
|
TD-3DCRT
|
5.3 ± 1.8
| |
|
TD-IMRT
|
4.5 ± 1.2
|
NS
|
|
FIF
|
4.2 ± 1.8
|
p < 0.05
|
|
HEART
|
V
25Gy
(%)
|
TD-3DCRT
|
5.5 ± 4.6
| |
|
TD-IMRT
|
3.4 ± 3.1
|
p < 0.01
|
|
FIF
|
3.4 ± 3.6
|
p < 0.01
|
|
MHD (Gy)
|
TD-3DCRT
|
4.0 ± 2.2
| |
|
TD-IMRT
|
3.0 ± 1.4
|
p < 0.05
|
|
FIF
|
3.0 ± 1.6
|
p < 0.01
|
|
CONTRALATERAL LUNG
|
D
0.1cc
(Gy)
|
TD-3DCRT
|
1.8 ± 0.6
| |
|
TD-IMRT
|
1.5 ± 0.5
|
p < 0.01
|
|
FIF
|
2.3 ± 0.9
|
p < 0.001
|
|
CONTRALATERAL BREAST
|
D
0.1cc
(Gy)
|
TD-3DCRT
|
3.4 ± 1.9
| |
|
TD-IMRT
|
2.3 ± 1.3
|
p < 0.05
|
|
FIF
|
4.3 ± 3.0
|
NS
|
|
D
mean
(Gy)
|
TD-3DCRT
|
0.43 ± 0.09
| |
|
TD-IMRT
|
0.38 ± 0.07
|
p < 0.05
|
|
FIF
|
0.52 ± 0.12
|
p < 0.001
|
|
Normal tissues external to PTV
|
D
2cc
(%)
^
|
TD-3DCRT
|
8.3 ± 2.3
| |
|
TD-IMRT
|
5.0 ± 1.4
|
p < 0.001
|
| | |
FIF
|
4.4 ± 1.3
|
p < 0.001
|
- Statistically significant differences between TD-3DCRT and the other techniques were considered significant for p < 0.05.
- *Volumes of ipsilateral lung receiving 30 Gy and 40 Gy were calculated for TD-3DCRT plan class patients only.
- ^as percentage of Rx.
- Two-tailed p values from paired Wilcoxon test.
- Data presented as mean ± standard devation.
