Radiation treatment with volumetric modulated arc therapy of hepatocellular carcinoma patients. Early clinical outcome and toxicity profile from a retrospective analysis of 138 patients

Table 3 Summary of the mean probability of survival factorized according to significant variables

Factor	Probability of survival (months) [95% C.I.]	P value
Sex	Male: 13.1 [11.1 – 15.1]	0.05
	Female: 15.2 [11.4 – 19.0]
Portal vein thrombosis	No: 17.7 [14.9 – 20.5]	<0.001
	Yes: 10.1 [7.9 - 12.3]
BCLC stage	A: 25.7 [20. – 30.9]	<0.001
	B: 20.1 [16.3 – 23.9]
	C: 13.5 [11.7 – 15.4]
Child-Pugh	A: 14.8 [12.6 – 17.1]	0.02
	B: 9.9 [7.3 – 12.6]
Hepatitis	No: 16.6 [12.1 – 21.1]	0.05
	B: 10.9 [8.6 – 13.3]
	C: 16.3 [12.9 – 19.7]
	B&C: 10.5 [4.1 – 16.8]
Baseline AFP	Baseline: 17.2 [12.8 – 21.6]	0.03
	Low risk:14.6 [11.5 – 17.7]
	High risk:9.3 [7.7 – 10.9]
Tumour localisation	Right lobe: 14.6 [11.5 – 17.6]	0.03
	Left lobe: 20.0 [15.7 – 24.3]
	Bilateral: 11.8 [9.4 – 14.2]
Total dose	45 Gy: 8.6 [5.1 – 12.1]	0.01
	60 Gy: 13.5 [11.4 – 15.5]
	66 Gy: 25.9 [21.1 – 30.7]
Volume of normal liver Receiving >15Gy	<30%: 21.0 [17.6 – 24.4]	0.001
	>30%: 18.6 [16.9 – 20.4]

ISSN: 1748-717X