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Table 6 Genes from downregulated network

From: Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland

Gene Full name Role in cancer quoted from literature
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 “Celsr2 was down-regulated in one cell line and in 7% of breast cancers”[38].
PRKCB protein kinase C, beta PRKCB has been observed to be downregulated in estrogen receptor negative breast cancer[39].
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog. Also known as C-Kit; CD117 Loss of c-kit expression has been reported in 80-90% of breast cancer specimens, suggesting a possible role in the development of tumors[40].
MAP2 microtubule-associated protein 2 “Elevation of MAP2 in breast cancer cell lines led to increased paclitaxel sensitivity” [41].
TDGF1 teratocarcinoma-derived growth factor 1. Also known as CR; CRGF; CRIPTO “Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis”[42].
ELF1 E74-like factor 1 “All of the mouse and most human mammary tumors also displayed decreased expression of genes known to inhibit cell proliferation, including NFKBIA (IKBalpha), GADD45B, and CDKN1A (p21); transcription-related genes such as CEBP, JUN, JUNB, and ELF1;….”[43].
RUNX1 runt-related transcription factor 1 “Furthermore, we found that RUNX1 expression was reduced in high-grade primary breast tumors compared to low/mid-grade tumors”[44].
TYMS thymidylate synthetase “Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case–control study”[45].
  1. A number of genes identified with the downregulated networks are associated with breast cancer.