Table 6 Genes from downregulated network
From: Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
Gene | Full name | Role in cancer quoted from literature |
|---|---|---|
CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | “Celsr2 was down-regulated in one cell line and in 7% of breast cancers”[38]. |
PRKCB | protein kinase C, beta | PRKCB has been observed to be downregulated in estrogen receptor negative breast cancer[39]. |
KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog. Also known as C-Kit; CD117 | Loss of c-kit expression has been reported in 80-90% of breast cancer specimens, suggesting a possible role in the development of tumors[40]. |
MAP2 | microtubule-associated protein 2 | “Elevation of MAP2 in breast cancer cell lines led to increased paclitaxel sensitivity” [41]. |
TDGF1 | teratocarcinoma-derived growth factor 1. Also known as CR; CRGF; CRIPTO | “Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis”[42]. |
ELF1 | E74-like factor 1 | “All of the mouse and most human mammary tumors also displayed decreased expression of genes known to inhibit cell proliferation, including NFKBIA (IKBalpha), GADD45B, and CDKN1A (p21); transcription-related genes such as CEBP, JUN, JUNB, and ELF1;….”[43]. |
RUNX1 | runt-related transcription factor 1 | “Furthermore, we found that RUNX1 expression was reduced in high-grade primary breast tumors compared to low/mid-grade tumors”[44]. |
TYMS | thymidylate synthetase | “Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case–control study”[45]. |