Table 4 Downregulated networks with score ≥8 are presented
From: Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
ID | Molecules in Network | Score | Focus Molecules | Top Functions |
|---|---|---|---|---|
1 | AGTR1, ARHGAP17, BAMBI, BARD1, BCL9, BRCA1, BRCC3, BRE, CELSR2, FURIN, GLP2R, Gp49a/Lilrb4, HNRNPF, Hsd3b4 (includes others), IFIT2, IL12 (complex), ITGB1, JUN, mir-31, Ms4a4b (includes others), MYD88, NAB2, NR3C1, PLCG1, PLXNB1, PRKCB, RPS3A, RRAD, SEMA4D, SERPINB5, ST6GAL1, Talin, TGFB1, TIAM1, TRAF3 | 26 | 16 | Cell Morphology, Cellular Growth and Proliferation, Hematological System Development and Function |
2 | ACPP, ACTG1, Actin, ADCY7, AKAP12, Akt, CAMK2B, DEFA1 (includes others), DGAT1, DHCR7, ERK1/2, EZR, FSH, GPRC5A, GRIN1, HSD17B1, KIT, LAT2, Lh, LYN, MAP2, MAP2K2, MME, MS4A2, Myosin, p85 (pik3r), PIK3AP1, PRKAR2B, PRKCB, SC4MOL, SH3BP2, SLC6A3, TDGF1, TYRO3, UNC119 | 24 | 15 | Cellular Compromise, Inflammatory Response, Cell Signaling |
3 | AHR, B4GALNT1, BAZ1A, C1orf38, C5AR1, CD1D, ELF1, GHRH, HDAC1, HIPK2, IFNA1/IFNA13, IFNG,IL4, INSM2, Lyz1/Lyz2, MAFB, MMP11, MTA3, NEUROD1, Nuclear factor 1, OAS1, OAS2, PCSK1, PCSK2, PPP4C, PPP5C, RB1, Rb, Runx1, SIN3B, SLC17A2, TFCP2, TNFSF11, TP53, TYMS | 24 | 15 | Tissue Morphology, Cancer, Gene Expression |
4 | ACSL1, ADAM17, APOBEC3B, CASP7, CHSY3, CLMN, FDFT1, FDPS, HLA-C, HMGCR, HSF1, HSPA1A/HSPA1B, IDI1, Klra4 (includes others), LSS, NR1H3, PPP1R15A, RAI14, RALGPS2, RBL1, RPS6, SCNN1A, SCNN1B, SCNN1G, SQLE, SREBF2, SYMPK, TNF, TP73, TSC2, WSB1, WT1, YWHAG, YY1, ZNF267 | 18 | 12 | Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism |