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Table 3 Upregulated networks with score ≥8 are presented

From: Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland

ID Molecules in Network Score Focus Molecules Top Functions
1 26sProteasome, ACHE, AChR, Akt, AQP4, BIN1, CAMK2A, CHRNA1, Creb,ERK1/2, FRZB, HSPA1L, IDE, ISL1, KCNC1, KIAA0368, KIF1B, MYOD1, MYOG, NES, NFkB (complex),NOL3, P2RY2, PDGF BB, PGK1, PLCG1, PPARGC1A, PRKCQ, RAPSN, RNF217, RXRG, S100B, SLC37A4, SNTA1, THPO 44 28 Cell Death, Neurological Disease, Cellular Development
2 ALDOA, ARPP21, ATP1A1, ATP1B1, ATP2A2, ATP6V0E2, BCL6, C15orf63, CIITA, ECSIT, FXYD4, Gapdh (includes others), Gm9790/Higd1a, GNAO1, HNRNPUL1, HSP90AB1, HTT, IL5, LDLR, NAA15, NDUFA12, PKM2, PMP22, POU3F1, RAB3A, RPH3A, SACS, SLC16A3, SPI1, SQSTM1, SYN2, TPI1, TRAF6, TUBA3C/TUBA3D, XBP1 21 17 Genetic Disorder, Neurological Disease, Skeletal and Muscular Disorders
3 ACTA1, ACTN1, AKAP6, ATP2B1, CDK16, CPE, ELL2, FSH, FYCO1, GK, GOT1, GPCPD1, IPO13, KIDINS220, LBX1, Lh, LIF, MAP1LC3B, NANOG, NOL3, PAX6, PCSK1N, PDE4D, PGK1, PHACTR2, PPFIA4, PPP2R5B, PRKAR1A, PRKAR2A, PSMD1, Ryr1l, SNAP23, STX3, TPM1 (includes EG:22003), VAMP8 19 16 Reproductive System Development and Function, Cellular Development, Cellular Growth and Proliferation
4 ABCC9, ALDOA, ATP1A1, CACNA1A, CACNA1B, CACNB1, CACNB4, CDH15, CTNNB1, DLG4, GOT2, HTT, IDH2, IL5, KCNJ11, KRAS, LDHA, LDHB, MYC, PCLO, PITX2, PRKCE, SCN1B, SCN2B, SLC25A4, SLC27A1, SYT1, SYT2, TP53, TPI1, TRIO, UGP2, VDAC1 16 14 Molecular Transport, Genetic Disorder, Carbohydrate Metabolism
5 AHR, APAF1, ATP1B2, BMI1, CAB39, CCNG1, CHEK2, CIITA, CREBBP, E2F6, ESRRG, Estrogen Receptor, HIST1H1A, Hist2h4 (includes others), HSP90AA1, MAPK12, MCM3, NFIC, Pcp4l1, PHC1, PLA2G12A, PRNP, RAD51AP1, Rb, RING1, SFTPC, SMARCA4, SMARCD3, STK11, STRADB, STUB1, Thymidine Kinase, TP53, TUBA8, UBE2B 16 14 Cell Cycle, Cell Death, Hematological System Development and Function
6 ATF3, B3GALT1,Calcineurin protein(s), Calmodulin, CCNA1, CIITA, CISH, CORO6, CREB1, CYP8B1, F2, FEM1A, GDF1, Gsk3, GSTA5, HSD17B7, HSPA8, IL1B, IL1R1, INSR, KCNQ5, Mapt, OPA3, PLCG1, PMS1, PPARGC1A, PSEN1, RORA, SATB1, SERPINA3, SIX1, SLC25A25, SOD1, TUBA4A, USP13 16 14 Cell Death, Neurological Disease, Tissue Morphology
7 ACSL1, APOA4, BCL2, CITED2, CPT1B, CRYAB, E2F1, EYA4, FOXC2, Fundc2, GSTA3, Ins1, ITGB6, KPNA3, Ldh, LEP, NEB, NEU2, NFKB1, PCSK1, POU2F1, PPARGC1A, PPP1R3A, PTGES, PTGS2, SOX6, SP1, SPTB, TMCC2, TNF, TNIK, TRAF2, TSPO, UCP3, ZFP36 16 14 Energy Production, Lipid Metabolism, Small Molecule Biochemistry
8 APOA4, ATF3, CD3, CD80, CD86, CEBPB, CIITA, COL1A1, COX5A, COX6B1, CPEB3, EFCAB6, ELAVL1, Gsk3, HELT, HSD11B1, HSPB2, IDH3B, IFNG, IL4, IL1RN, IRF1, NEIL2, NEUROG1, NR3C2, NRF1, POLR2A, Rac, TACC2, TCF7L2, TRAK1, TRAM2, USP2, VLDLR, WWP2 14 13 Cellular Growth and Proliferation, Hematological System Development and Function, Tissue Development
9 ACTA1, ACTC1, AGTR1, C14orf166, CUL5, DCT, DDX1, DMPK, DOT1L, EIF1AY, ENO1, ENPP4, FXR1, FXYD1, FZD9, Histone h3, HRASLS, JUN, MECP2, MLLT3, MYH1, MYH2, MYH4, PABPC4, RELN, SCNN1A, SGK1, STAU1, SYNCRIP, TCF4, THOC4, UCP1, UQCRC1, YWHAZ, YY1 14 13 Cellular Function and Maintenance, Molecular Transport, Cellular Assembly and Organization
10 ABHD5, ADAM12, ADCK3, ADM, CALCRL, CD40LG, DOK7, ENDOG, ERBB2, FILIP1, FLNA, G6pd2, GNB2L1, HIF1A, Hsp70, Hsp90, HSP90AA1, IGF1R, ITGB1, KDM3A, MUSK, NR3C1, NRG1 (includes EG:112400), PACSIN3, PAK1, PGM1, PLIN5, PRKCE, PSEN1, Rac, RAMP1, SRC, STUB1, TLN2, TTN 11 11 Cell Death, Cell-To-Cell Signaling and Interaction, Nervous System Development and Function
11 ADAM10, ADIPOR1, ADRA1B, CCND2, CCND3, COX7A1, CXCL10, CXCL12, CYP11A1, CYP7A1, DMD, DTNA, DUSP26, FSHB, HIPK3, HSF4, ITGB4, LCK, MAPK3, MAPRE3, MET, Mlc, NFKB2, NR5A1, PI3K (complex), PIN1, PITX1, PLEC, PRKCZ, RAC1, Ras, SOX9, SYNC, TCEA3, THRB 10 10 Cancer, Tissue Development, Embryonic Development
12 ABCB4, AGER, AIMP2, CD2, CD28, CD40, CD59, CD86, CD40LG, DISC1, DNM2, DYRK1B, FGFR1, GRB2, GRB14, HGF, IL2, IL12 (complex), JAK1, JAK2, MET, P38 MAPK, PDE4A, PDGFA, PDGFRB, PIK3C2B, PLCG1, PTPN2, ASA1, SH2B3, Sos, SQSTM1, WAS, ZAP70, ZFP106 8 9 Cellular Movement, Cell Death, Immune Cell Trafficking
  1. Highlighted genes are from the microarray dataset.