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Table 3 Results of concurrent chemoradiation

From: The technical feasibility of an image-guided intensity-modulated radiotherapy (IG-IMRT) to perform a hypofractionated schedule in terms of toxicity and local control for patients with locally advanced or recurrent pancreatic cancer

Author Treatment regimen No. of patients Gastrointestinal toxicity (≥ Grade 3) Hematologic toxicity (≥ Grade 3) Local failure rate Median PFS (months) Median OS (months)
Cohen et al.[7] RT 59.4 Gy/5-FU+mitomycin 55 13% 20% NA 5.1 8.4
Ishii et al.[8] RT 50.4 Gy/5-FU 20 15% 0% 35% 4.9 10.3
Kornek et al.[9] RT 55 Gy/5-FU+cisplatin 38 18% 18% NA 10 14
Boz et al.[10] RT 59.4 Gy/5-FU 42 4% 16% 51% 6.2 9.1
Magnino et al.[12] RT 45 Gy/GEM 23 30% 39% 22% NA 12
Blackstock et al.[13] RT 50.4 Gy/GEM 39 41% 69% 15% NA 7.9
Okusaka et al.[14] RT 50.4 Gy/GEM 38 33% 52% 6% 4.4 9.5
Li et al.[15] RT 50.4-61.2 Gy/GEM 18 28% 28% 34% 7.1 14.5
Murphy et al.[16] *RT 36 Gy/GEM 74 11% 24% 26% NA 11.2
This study *RT 50 Gy/5-FU 10 0% 17% 8% 7.6 12.1
  1. Abbreviations: PFS = progression-free survival; OS = overall survival; RT = radiotherapy; 5-FU = 5-fluorouracil; GEM = gemcitabine; NA = not available.
  2. * Hypofractionated CCRT.