Skip to main content

Table 3 Results of concurrent chemoradiation

From: The technical feasibility of an image-guided intensity-modulated radiotherapy (IG-IMRT) to perform a hypofractionated schedule in terms of toxicity and local control for patients with locally advanced or recurrent pancreatic cancer

Author

Treatment regimen

No. of patients

Gastrointestinal toxicity (≥ Grade 3)

Hematologic toxicity (≥ Grade 3)

Local failure rate

Median PFS (months)

Median OS (months)

Cohen et al.[7]

RT 59.4 Gy/5-FU+mitomycin

55

13%

20%

NA

5.1

8.4

Ishii et al.[8]

RT 50.4 Gy/5-FU

20

15%

0%

35%

4.9

10.3

Kornek et al.[9]

RT 55 Gy/5-FU+cisplatin

38

18%

18%

NA

10

14

Boz et al.[10]

RT 59.4 Gy/5-FU

42

4%

16%

51%

6.2

9.1

Magnino et al.[12]

RT 45 Gy/GEM

23

30%

39%

22%

NA

12

Blackstock et al.[13]

RT 50.4 Gy/GEM

39

41%

69%

15%

NA

7.9

Okusaka et al.[14]

RT 50.4 Gy/GEM

38

33%

52%

6%

4.4

9.5

Li et al.[15]

RT 50.4-61.2 Gy/GEM

18

28%

28%

34%

7.1

14.5

Murphy et al.[16]

*RT 36 Gy/GEM

74

11%

24%

26%

NA

11.2

This study

*RT 50 Gy/5-FU

10

0%

17%

8%

7.6

12.1

  1. Abbreviations: PFS = progression-free survival; OS = overall survival; RT = radiotherapy; 5-FU = 5-fluorouracil; GEM = gemcitabine; NA = not available.
  2. * Hypofractionated CCRT.