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Table 1 Patient (n – 141) Characteristics and Univariate Analysis for Impact on Local Control

From: Definitive radiotherapy for early (T1-T2) Glottic Squamous cell carcinoma: a 20 year Cleveland clinic experience

Characteristic # of Patients(range or %) p value
Mean Age (yrs) at end of radiation 67 (33–94) 0.9055
Gender   0.3902
   male 125 (88.7%)  
   female 16 (11.3%)  
Race   0.1133
   Caucasian 119 (84.4%)  
   Non-caucasian 22 (15.6%)  
Median Pack Years 44 (0–135) 0.6769
Smoker   0.3530
   Never 12 (8.5%)  
   Former 92 (65.2%)  
   Current 32 (22.7%) 0.5568
   Unknown 5 (3.5%)  
Heavy Alchohol Use   0.0630
   Never (Reference) 89 (63.1%)  
   Former 21 (14.9%) 0.8836
   Current 19 (13.5%) 0.0222
   Unknown 12 (8.5%)  
Ant Commissure   0.0505
   Involved 71 (50.3%)  
   Non Involved 52 (36.9%)  
   Unknown 18 (12.8%)  
Tumor Bulk   0.6386
   Bulky 55 ( 39%)  
   Non bulky 86 ( 61%)  
Hemoglobin (g/dL) 14.2  
Grade   0.6614
   Well (Reference) 43 (30.5%)  
   Moderate 57 (40.4%) 0.7192
   Poor 14 (10%) 0.3646
   Unknown 27 (19.1%)  
Stage (T2b vs T1a/b/2a)   0.0205
   1a 65 ( 46%) 0.0033
   1b 21 (14.9%) 0.1766
   2a 29 (20.6%) 0.0621
   2b (Reference) 25 (17.7%)  
   Unknown 1 (1%)  
Subglottic Ext   0.0505
   Yes 18 (12.8%)  
   No 96 (68.1%)  
   Missing 27 (19.2%)  
Supraglottic Ext   0.4668
   Yes 30 (21.2%)  
   No 87 (61.7%)  
   Missing 24 (17%)  
Median Overall Treatment Time (wks) 6.5 (4–9.7)  
Radiation Dose (cGy) as Continous 6820 (6300–7264) 0.0367
   ≤66 Gy 45  
   > 66 Gy 96  
Median Dose/Fraction 212 (176–256) 0.1353
   ≤2Gy/fx 45 (31.9%)  
   >2Gy/fx 95 (67.4%)  
missing 1 (1%)  
Mean Follow-Up (month) 67.7 (0–239)