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Figure 5 | Radiation Oncology

Figure 5

From: Photon activated therapy (PAT) using monochromatic Synchrotron x-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy

Figure 5

Fluorescence microscopic image of radiation only (RO-5Gy) control group (A, C) and FeO-NP+5Gy radiation group (B, D); C and D are expanded view of A or B, respectively to show the cellular change in fluorescent color more clearly . The damaged shrunken nuclei indicate apoptosis, which was more frequently observed in (B) compared to (A). AO stained the damaged DNA, which altered the fluorescence. EB did not penetrate or showed less penetration into the cell nucleus in the control group. In contrast, EB entered the nuclei of the cells in the FeO-NP+5Gy group (D), reflecting the presence of more nuclear damage than the RO-5Gy group (C).

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Radiation Oncology

ISSN: 1748-717X

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