Skip to main content
Figure 1 | Radiation Oncology

Figure 1

From: Photon activated therapy (PAT) using monochromatic Synchrotron x-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy

Figure 1

Schematic diagrams of radiation dose calibration (A), in vitro (B) and in vivo (C) PAT experiments. A sample holder containing the cells was placed vertically and facing the horizontal beam. Anesthetized mice were placed on the sample stage. Radiation dose was delivered with either 5.0 Gy/100 ms at the surface of sample holder for cell or 2.4 Gy/s at a skin depth of 2 mm for animal model using a fast shutter with time resolution of 10 ms. For entering dose of 50 Gy/s, 0.115 Gy/s could be estimated as an exit dose rate in 4 mm-depth tumor, and 2.4 Gy/s in 2 mm-depth cell sample holder, respectively. An acryl block with a hole was used to prevent unnecessary exposure of either Gafchromic film or the normal tissue surrounding the tumor.

Back to article page

Radiation Oncology

ISSN: 1748-717X

Contact us