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Table 3 Localization and pattern of tumor recurrences in relation to the clinical target volumes

From: Outcome and patterns of failure after postoperative intensity modulated radiotherapy for locally advanced or high-risk oral cavity squamous cell carcinoma

Site of Primary T N R ECE Flap Systemic therapy Time to recurrence (yrs) Compartment of recurrence Localization and pattern of recurrence Relation of recurrence to CTV 54 Relation of recurrence to CTV60-66
Floor of mouth 4 2b c Yes Yes Yes 0.2 Local Outside FTB, not involving flap, multifocal Marginal Marginal
        0.8 Distant Lung n.a n.a
Floor of mouth 1 2b c No No Yes 3.1 Local Outside FTB, ipsilateral dorsal edge of tongue, unifocal Marginal Marginal
Floor of mouth 4 2b c Yes Yes Yes 0.7 Local Within FTB and flap, multifocal In Marginal
        0.7 Distant Lung n.a n.a
Lower alveolar ridge 4 2b 1 Yes Yes No 0.3 Local Within FTB and flap, multifocal   
        0.3 Regional Ipsilateral neck, multifocal In In
        0.4 Distant Lung, Pleura, Skin, Liver n.a n.a
Tongue 2 2b c No No No 0.5 Local Within FTB, unifocal In Marginal
        0.5 Regional Bilateral neck (ipsilateral bulky), multifocal   
Tongue 2 2b 0 No Yes No 0.2 Local Within FTB and flap, unifocal   
        0.2 Regional Bilateral neck, multifocal In Marginal
        0.2 Distant Pleura n.a n.a
Buccal mucosa 2 2b 1 Yes Yes Yes 0.1 Local Within bed of surgical resection and flap, multifocal Marginal Marginal
        0.1 Regional Contralateral neck, unifocal   
Tongue 3 2b 0 Yes Yes No 0.7 Local Within FTB and flap, multifocal In Marginal
        0.7 Regional Contralateral neck, unifocal   
Tongue 2 0 0 No No No 0.7 Local Within FTB, unifocal Marginal Marginal
        0.7 Regional Contralateral neck, multifocal   
Tongue 3 2c c Yes Yes Yes 0.7 Regional Contralateral neck, unifocal In In*
Tongue 1 0 c No No No 1.3 Regional Contralateral neck, unifocal Out Out
Lower alveolar ridge, edge of tongue 4 0 0 No Yes No 0.5 Regional Outside FTB, not involving flap, extending to ipsilateral base of skull and Fossa infratemporalis, unifocal Out Out
  1. Abbreviations: T tumor classification, N nodal classification, R resection margin, c close (< 3 mm), CTV clinical target volume, n.a. not applicable;
  2. FTB former tumor bed, CTV clinical target volume, *this patient was one of the two patients who received a total dose of 72 Gy, the regional
  3. recurrence was inside the CTV72Gy.