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Table 3 Localization and pattern of tumor recurrences in relation to the clinical target volumes

From: Outcome and patterns of failure after postoperative intensity modulated radiotherapy for locally advanced or high-risk oral cavity squamous cell carcinoma

Site of Primary

T

N

R

ECE

Flap

Systemic therapy

Time to recurrence (yrs)

Compartment of recurrence

Localization and pattern of recurrence

Relation of recurrence to CTV 54

Relation of recurrence to CTV60-66

Floor of mouth

4

2b

c

Yes

Yes

Yes

0.2

Local

Outside FTB, not involving flap, multifocal

Marginal

Marginal

       

0.8

Distant

Lung

n.a

n.a

Floor of mouth

1

2b

c

No

No

Yes

3.1

Local

Outside FTB, ipsilateral dorsal edge of tongue, unifocal

Marginal

Marginal

Floor of mouth

4

2b

c

Yes

Yes

Yes

0.7

Local

Within FTB and flap, multifocal

In

Marginal

       

0.7

Distant

Lung

n.a

n.a

Lower alveolar ridge

4

2b

1

Yes

Yes

No

0.3

Local

Within FTB and flap, multifocal

  
       

0.3

Regional

Ipsilateral neck, multifocal

In

In

       

0.4

Distant

Lung, Pleura, Skin, Liver

n.a

n.a

Tongue

2

2b

c

No

No

No

0.5

Local

Within FTB, unifocal

In

Marginal

       

0.5

Regional

Bilateral neck (ipsilateral bulky), multifocal

  

Tongue

2

2b

0

No

Yes

No

0.2

Local

Within FTB and flap, unifocal

  
       

0.2

Regional

Bilateral neck, multifocal

In

Marginal

       

0.2

Distant

Pleura

n.a

n.a

Buccal mucosa

2

2b

1

Yes

Yes

Yes

0.1

Local

Within bed of surgical resection and flap, multifocal

Marginal

Marginal

       

0.1

Regional

Contralateral neck, unifocal

  

Tongue

3

2b

0

Yes

Yes

No

0.7

Local

Within FTB and flap, multifocal

In

Marginal

       

0.7

Regional

Contralateral neck, unifocal

  

Tongue

2

0

0

No

No

No

0.7

Local

Within FTB, unifocal

Marginal

Marginal

       

0.7

Regional

Contralateral neck, multifocal

  

Tongue

3

2c

c

Yes

Yes

Yes

0.7

Regional

Contralateral neck, unifocal

In

In*

Tongue

1

0

c

No

No

No

1.3

Regional

Contralateral neck, unifocal

Out

Out

Lower alveolar ridge, edge of tongue

4

0

0

No

Yes

No

0.5

Regional

Outside FTB, not involving flap, extending to ipsilateral base of skull and Fossa infratemporalis, unifocal

Out

Out

  1. Abbreviations: T tumor classification, N nodal classification, R resection margin, c close (< 3 mm), CTV clinical target volume, n.a. not applicable;
  2. FTB former tumor bed, CTV clinical target volume, *this patient was one of the two patients who received a total dose of 72 Gy, the regional
  3. recurrence was inside the CTV72Gy.
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Radiation Oncology

ISSN: 1748-717X

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