Table 2 Treatment outcome analysis

Univariate analysis

Age (years)

>60

1.31 (0.42, 4.13) (0.64)

1.44 (0.24, 8.62) (0.69)

2.46 (0.65, 9.28) (0.18)

Sex

Male

0.92 (0.27, 3.07) (0.89)

0.75 (0.12, 4.48) (0.75)

1.81 (0.39, 8.44) (0.45)

KPS

≤70

1.20 (0.32, 4.44) (0.79)

0.94 (0.11, 8.46) (0.96)

0.74 (0.16, 3.42) (0.70)

T-classification

pT_3-4

1.73 (0.56, 5.37) (0.34)

2.44 (0.41, 14.58) (0.33)

1.43 (0.44, 4.70) (0.55)

N-classification

pN_2-3

4.71 (1.27, 17.45) (0.02)

114.6 (0.06, >1000) (0.22)

4.65 (1.23, 17.63) (0.02)

AJCC stage

IV

4.43 (0.97, 20.27) (0.05)

56.7 (0.04, >1000) (0.27)

4.13 (0.90, 19.10) (0.07)

Grading

G3

1.82 (0.58, 5.73) (0.31)

3.4 (0.57, 20.4) (0.18)

0.89 (0.24, 3.40) (0.87)

Resection margins

R1

0.65 (0.14, 2.98) (0.58)

0.78 (0.09, 6.96) (0.82)

1.73 (0.50, 5.93) (0.38)

ECE positive LN

yes

2.29 (0.74, 7.14) (0.15)

3.54 (0.58, 21.4) (0.17)

2.19 (0.66, 7.27) (0.20)

Chemotherapy*

yes

0.56 (0.18, 1.75) (0.32)

1.15 (0.19, 6.89) (0.88)

0.44 (0.13, 1.50) (0.20)

Flap reconstruction

yes

1.92 (0.58, 6.42) (0.29)

59.4 (0.04, >1000) (0.27)

2.48 (0.66, 9.35) (0.16)

Bilateral ND

yes

0.38 (0.10, 1.40) (0.15)

0.74 (0.12, 4.46) (0.75)

0.59 (0.17, 2.01) (0.40)

Gastrostomy tube

yes

1.68 (0.53, 5.30) (0.38)

1.70 (0.28, 10.17) (0.56)

1.03 (0.31, 3.38) (0.96)

Time OP to RT

> 6 weeks

0.59 (0.19, 1.89) (0.38)

0.73 (0.12, 4.37) (0.73)

0.68 (0.19, 2.35) (0.54)

Multivariate analysis

N-classification

pN_2-3

4.71 (1.27, 17.45) (0.02)

n.a.

4.65 (1.23, 17.63) (0.02)

AJCC stage

IV

1.68 (0.15, 18.51) (0.67)

n.a.

1.53 (0.14, 16.94) (0.73)