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Table 2 Vorinostat, hypoxia, and ionizing radiation - tumor growth delay

From: Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma

Treatment groups

TGD2x(days)

Compared to (group)

p-value

SW620 Pilot

   

HO

0.27 ± 1.9

C

0.7

IR-NO

5.47 ± 1.9

C

<0.001

IR-HO

2.33 ± 3.0

C

0.09

SW620 Main experiment

   

IR-NO

7.83 ± 5.9

C

0.02

IR-HO

−1.43 ± 3.6

C

0.4

VOR-IR-HO

6.07 ± 2.5

IR-HO

0.02

  1. TGD2x = tumor growth delay at 2-fold increase of relative tumor volume; C = control; HO = hypoxia; IR-NO = IR under normoxia; IR-HO = IR under hypoxia; VOR-IR-HO = vorinostat and IR under hypoxia.
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Radiation Oncology

ISSN: 1748-717X

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