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Table 1 Possible key factors affected by radiotherapy with respect to the phases of wound

From: Wound healing after radiation therapy: Review of the literature

Phase of wound healing Factors affected by radiation therapy
Inflammation TGFβ, VEGF, interleukin-1, interleukin-8, TNFα, IFN-γ
Proliferation TGFβ, VEGF, EGF, FGF, PDGF, NO
Remodelling MMP-1, MMP-2, MMP-12, MMP-13, TIMP
  1. Wound healing factors affected by radiation therapy.