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Figure 4 | Radiation Oncology

Figure 4

From: Preclinical evaluation of sunitinib, a multi-tyrosine kinase inhibitor, as a radiosensitizer for human prostate cancer

Figure 4

The effects of sunitinib on downstream signals. Both DU145 (A) and PC3 (B) cells were treated with sunitinib (40, 100, 250 nM) and harvested for western blot analysis 2 hours after irradiation (5 Gy). Cells were assessed for the effect of sunitinib on two key signaling proteins, ERK and AKT; both of which are involved in the radiation response and lie downstream of all three RTK targets, p-PDGFR-β, p-VEGFR2, and p-C-KIT. Actin was used as a loading control.

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