Figure 1

Expression of RTK’s detected by western blot analysis. Three prostate cell lines PC3, LNCaPs and DU145 were assessed for the presence of RTKs, shown to be targets of sunitinib (c-KIT, VEGFR-2, PDGFR- and FLT3). DU145 was found to be positive for all except for FLT3. PDGFR- was the only RTK found to be expressed in PC3 cells while LNCaPs were found to be negative for all four.