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Table 3 Dosimetric results

From: Phase I-II study of hypofractionated simultaneous integrated boost using volumetric modulated arc therapy for adjuvant radiation therapy in breast cancer patients: a report of feasibility and early toxicity results in the first 50 treatments

 

Parameter

All

Left breast

Right breast

PTVWB

Volume [cm3]

605.6 ± 313.9

702.5 ± 291.7

505.1 ± 309.5

 

Mean [Gy]

41.5 ± 1.3

41.5 ± 1.3

41.5 ± 1.4

 

D2% [Gy]

45.0 ± 1.3

44.8 ± 1.1

45.1 ± 1.5

 

D98% [Gy]

37.2 ± 2.9

37.2 ± 3.1

37.3 ± 2.8

 

V95% [%]

92.9 ± 12.8

93.0 ± 13.3

92.8 ± 12.6

 

V105% [%]

30.8 ± 16.8

30.9 ± 16.0

30.7 ± 18.0

PTVboost

Volume [cm3]

51.5 ± 45.9

54.11 ± 50.3

48.8 ± 41.7

 

Mean [Gy]

47.8 ± 1.0

47.7 ± 1.1

48.0 ± 0.9

 

D2% [Gy]

49.3 ± 0.9

49.1 ± 0.9

49.5 ± 0.9

 

D98% [Gy]

45.8 ± 1.4

45.7 ± 1.6

45.8 ± 1.3

 

V95% [%]

93.5 ± 19.9

92.5 ± 23.7

94.6 ± 15.4

 

V105% [%]

0.7 ± 2.1

0.2 ± 0.7

1.2 ± 2.9

Ipsilateral Lung

Mean [Gy]

8.7 ± 1.7

8.5 ± 1.7

8.9 ± 1.8

 

V5Gy [%]

61.9 ± 15.9

60.0 ± 16.1

63.9 ± 15.9

 

V20Gy [%]

8.6 ± 2.9

8.4 ± 2.8

8.8 ± 3.0

 

V25Gy [%]

4.1 ± 1.9

4.2 ± 1.9

3.9 ± 1.9

Contralateral Lung

Mean [Gy]

2.5 ± 0.9

2.6 ± 0.9

2.5 ± 1.0

 

V5Gy [%]

8.9 ± 9.9

8.8 ± 9.7

9.1 ± 10.4

Heart

Mean [Gy]

5.4 ± 2.0

6.5 ± 1.7

4.3 ± 1.8

 

D1cm3 [Gy]

20.4 ± 8.9

27.0 ± 4.4

13.1 ± 6.4

 

V18Gy [%]

2.0 ± 2.2

3.1 ± 3.3

0.5 ± 1.2

Skin 3 mm

Mean [Gy]

21.0 ± 1.6

21.4 ± 1.8

20.7 ± 1.4

 

V30Gy [cm3]

27.0 ± 12.5

29.6 ± 14.2

24.2 ± 9.9

 

V40Gy [cm3]

0.5 ± 0.9

0.6 ± 1.1

0.5 ± 0.7

Skin 5 mm

Mean [Gy]

23.3 ± 1.7

23.6 ± 1.8

22.9 ± 1.4

 

V30Gy [cm3]

88.3 ± 26.7

96.0 ± 28.5

80.3 ± 22.6

 

V40Gy [cm3]

5.9 ± 5.6

6.1 ± 6.5

5.6 ± 4.6

Ribs

D1cm3 [Gy]

37.4 ± 2.6

37.4 ± 2.7

37.5 ± 2.5

 

V40Gy [cm3]

3.2 ± 3.6

3.2 ± 3.9

3.2 ± 3.4

Contralateral Breast

Mean [Gy]

3.3 ± 5.8

4.1 ± 8.2

2.5 ± 0.6

 

V5Gy [%]

7.6 ± 15.0

10.0 ± 20.3

5.1 ± 4.8

Healthy Tissue

Mean [Gy]

3.4 ± 0.7

3.3 ± 0.6

3.5 ± 0.7

 

V10Gy [%]

9.2 ± 2.2

8.8 ± 1.9

9.6 ± 2.3

 

DoseInt [Gy*cm3*104]*

7.2 ± 2.0

7.6 ± 1.9

6.8 ± 2.0

  1. * DoseInt = integral dose.