Table 3 Multivariate analysis of PALN recurrence using CEA levels integrated into SCC-Ag level < 10 ng/mL
Parameters | Number | Hazard ratio (95% CI) | p value |
|---|---|---|---|
Age | Â | -- | 0.323 |
   < 50 | 58 | reference |  |
   50-60 | 59 | -- | 0.155 |
   > 60 | 71 | -- | 0.233 |
Stage | Â | -- | 0.609 |
   I | 22 | reference |  |
   II | 145 | -- | 0.629 |
   III-IVA | 41 | -- | 0.372 |
Parametrial score | Â | -- | 0.121 |
   0 | 36 | reference |  |
   1-3 | 103 | -- | 0.111 |
   4-6 | 49 | -- | 0.040 |
Tumor size | Â | Â | 0.651 |
   ≤ 5.0 | 48 | reference |  |
   > 5.0 | 53 | -- | 0.517 |
   unknown | 87 | -- | 0.864 |
Positive pelvic node | Â | -- | 0.075 |
Hemoglobin < 12 g/dL | Â | -- | 0.303 |
Smoking | Â | -- | 0.528 |
Field size (< 18 cm) | Â | -- | 0.874 |
Pretreatment tumor marker (ng/mL) | Â | Â | < 0.001 |
   SCC-Ag < 10 and CEA < 10 | 113 | reference |  |
   SCC-Ag < 10 and CEA ≥ 10 | 15 | 8.838 (3.199-24.419) | < 0.001 |
   SCC-Ag 10-40 | 42 | 4.246 (1.706-10.569) | 0.002 |
   SCC-Ag ≥ 40 | 18 | 12.551 (4.811-32.747) | < 0.001 |