The role of the maximum involvement of biopsy core in predicting outcome for patients treated with dose-escalated radiation therapy for prostate cancer

Table 4 Univariate and Multivariate Models For Freedom From Biochemical Failure

Variable	Univariate Analysis		Multivariate Model # 1 Maximum Core Only		Multivariate Model #2 MIBC + Percent Positive Cores		Multivariate Model #3 MIBC + Percent Cancer Volume
	p-value	Hazard Ratio (95% CI)	p-value	Hazard Ratio (95%CI)	p-value	Hazard Ratio (95%CI)	p-value	Hazard Ratio (95%CI)
Age	0.62	0.99 (0.97-1.02)	0.23	0.99 (0.96-1.01)	0.40	0.99 (0.97-1.01)	0.48	0.99 (0.97-1.02)
PSA	<0.0001	5.7 (3.6-9.5)	<0.0001	4.6 (2.3-9.3)	<0.0001	4.7 (2.3-9.7)	0.0001	4.5 (2.2-9.4)
T-stage
T1-T2a	Reference		Reference		Reference		Reference
T2b-T2c	0.0065	2.0 (1.2-3.3)	0.48	1.2 (0.70-2.2)	0.82	1.1 (0.59-1.9)	1.0	1.00 (0.55-1.8)
T3-4	<0.0001	3.3 (1.9-5.6)	0.67	1.2 (0.60-2.2)	0.83	1.1 (0.55-2.1)	0.91	0.96 (0.49-1.9)
Gleason Score
2-6	Reference		Reference		Reference		Reference
7	0.0004	2.6 (1.5-4.3)	0.17	1.6 (0.82-3.1)	0.45	1.3 (0.67-2.5)	0.58	1.2 (0.61-2.4)
8-10	<0.0001	4.9 (2.8-8.9)	0.02	2.8 (1.2-6.9)	0.027	2.8 (1.1-6.7)	0.07	2.3 (0.93-5.8)
ADT Use
No	Reference		Reference		Reference		Reference
Yes	0.0001	2.2 (1.5-3.3)	0.82	0.94 (0.53-1.7)	0.68	0.88 (0.49-1.6)	0.80	0.93 (0.51-1.7)
Pelvic RT
No	Reference		Reference		Reference		Reference
Yes	<0.0001	2.7 (2.0-3.8)	0.32	0.68 (0.32-1.5)	0.20	0.59 (0.27-1.3)	0.30	0.65 (0.29-1.5)
RT Dose	0.10	1.2 (0.97-1.4)	0.95	1.01 (0.78-1.3)	0.71	1.05 (0.82-1.3)	0.70	1.05 (0.81-1.4)
Cancer Volume Metrics
Maximum Biopsy Core	<0.0001	1.02 (1.01-1.02)	0.12	1.01 (1.00-1.02)	0.27	1.00 (0.99-1.02)	0.33	1.00 (1.0-1.02)
Percent Positive Cores	<0.0001	1.02 (1.01-1.03)			0.019	1.01 (1.00-1.02)
Percent Cancer Volume	<0.0001	1.02 (1.02-1.03)					0.03	1.02 (0.98-1.04)

All analyses done by Cox Proportional Hazards regression with variables modeled as continuous variables except where indicated.
Abbreviations: MIBC = maximum involvement of biopsy core; PSA = Prostate Specific Antigen; ADT = Androgen Deprivation Therapy; RT = Radiation Therapy; HR = hazard ratio; CI = confidence interval.

ISSN: 1748-717X