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Table 4 Univariate and Multivariate Models For Freedom From Biochemical Failure

From: The role of the maximum involvement of biopsy core in predicting outcome for patients treated with dose-escalated radiation therapy for prostate cancer

Variable Univariate Analysis Multivariate Model # 1 Maximum Core Only Multivariate Model #2 MIBC + Percent Positive Cores Multivariate Model #3 MIBC + Percent Cancer Volume
  p-value Hazard Ratio (95% CI) p-value Hazard Ratio (95%CI) p-value Hazard Ratio (95%CI) p-value Hazard Ratio (95%CI)
Age 0.62 0.99 (0.97-1.02) 0.23 0.99 (0.96-1.01) 0.40 0.99 (0.97-1.01) 0.48 0.99 (0.97-1.02)
PSA <0.0001 5.7 (3.6-9.5) <0.0001 4.6 (2.3-9.3) <0.0001 4.7 (2.3-9.7) 0.0001 4.5 (2.2-9.4)
T-stage
T1-T2a Reference Reference Reference Reference
T2b-T2c 0.0065 2.0 (1.2-3.3) 0.48 1.2 (0.70-2.2) 0.82 1.1 (0.59-1.9) 1.0 1.00 (0.55-1.8)
T3-4 <0.0001 3.3 (1.9-5.6) 0.67 1.2 (0.60-2.2) 0.83 1.1 (0.55-2.1) 0.91 0.96 (0.49-1.9)
Gleason Score
2-6 Reference Reference Reference Reference
7 0.0004 2.6 (1.5-4.3) 0.17 1.6 (0.82-3.1) 0.45 1.3 (0.67-2.5) 0.58 1.2 (0.61-2.4)
8-10 <0.0001 4.9 (2.8-8.9) 0.02 2.8 (1.2-6.9) 0.027 2.8 (1.1-6.7) 0.07 2.3 (0.93-5.8)
ADT Use
No Reference Reference Reference Reference
Yes 0.0001 2.2 (1.5-3.3) 0.82 0.94 (0.53-1.7) 0.68 0.88 (0.49-1.6) 0.80 0.93 (0.51-1.7)
Pelvic RT
No Reference Reference Reference Reference
Yes <0.0001 2.7 (2.0-3.8) 0.32 0.68 (0.32-1.5) 0.20 0.59 (0.27-1.3) 0.30 0.65 (0.29-1.5)
RT Dose 0.10 1.2 (0.97-1.4) 0.95 1.01 (0.78-1.3) 0.71 1.05 (0.82-1.3) 0.70 1.05 (0.81-1.4)
Cancer Volume Metrics
Maximum Biopsy Core <0.0001 1.02 (1.01-1.02) 0.12 1.01 (1.00-1.02) 0.27 1.00 (0.99-1.02) 0.33 1.00 (1.0-1.02)
Percent Positive Cores <0.0001 1.02 (1.01-1.03)    0.019 1.01 (1.00-1.02)   
Percent Cancer Volume <0.0001 1.02 (1.02-1.03)      0.03 1.02 (0.98-1.04)
  1. All analyses done by Cox Proportional Hazards regression with variables modeled as continuous variables except where indicated.
  2. Abbreviations: MIBC = maximum involvement of biopsy core; PSA = Prostate Specific Antigen; ADT = Androgen Deprivation Therapy; RT = Radiation Therapy; HR = hazard ratio; CI = confidence interval.