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Table 5 SIB comparison using IMRT and VMAT

From: A dosimetric comparison of 3D conformal vs intensity modulated vs volumetric arc radiation therapy for muscle invasive bladder cancer

Variable IMRT BOOST VMAT BOOST  
  Mean(min-max, st dev) Mean(min-max, st dev) p-value
CTV MAX 76.1(75.1-77.2, 0.69) 77.4(76–78.4, 0.66) 0.004
CTV MIN 63.2(61.7-66.3, 1.33) 61.5(60.2-63.5, 1) 0.011
CTV MEAN 71.5(68.7- 74.3, 1.75) 71.2(68.6-73.2, 1.43) 0.398
CTV MEDIAN 72.3(67–74.6, 2.88) 71.9(66.9-74.1, 2.62) 0.068
CTV D98% 64.8(62.8-69.7, 2.2) 64.4(62.9-68, 1.73) 0.625
CTV D2% 75.4(74.6-76.4-0.55) 76(75–76.6, 0.48) 0.007
CTV D99 > 60.8Gy 64.5(62.5-69.1, 2.08) 63.8(62.4-69.1, 1.85) 0.044
PTV MAX 76.7(75.1-78.3, 0.9) 78.3(76.1-80.2, 1.15) 0.006
PTV MIN 55.1(47.3-57.4, 2.9) 55.5(15.5-57.6, 1.93) 0.476
PTV MEAN 68.8(67.5-70.4, 1.2) 68.8(67–70.4, 0.89) 1.000
PTV MEDIAN 67.9(65.5-71.6, 2.58) 67.7(65.9. 70.1, 1.37) 0.688
PTV V95% (cc) 557(254–798, 171) 552(267–804, 173) 0.756
PTV D95% 63.1(62.5-63.7, 0.46) 62.9(62–63.9, 0.56) 0.450
PTV D2% 75.5(74.5-76.3, 0.49) 75.9(73.4-76.8, 0.96) 0.056
PTV D50% 68.2(65.8-71.6, 2.45) 67.7(65.9-70.1, 1.37) 0.350
PTV D99 > 60.8Gy 61.5(60.5-62.5, 0.58) 61.9(60.3-70, 2.73) 0.307
PTV D98 > 60.8Gy 62.2(61.5-62.9, 0.47) 61.9(61–63, 0.63) 0.307
BOOST GTV MAX 75.7(74.9-76.9, 0.57) 76.6(75.4-77.6, 0.74) 0.006
BOOST GTV MIN 73.2(72.3-74, 0.52) 72.9(71–77.2, 1.58) 0.142
BOOST GTV MEAN 74.5(74.4-74.5, 0.02) 74.5(74.4-74.5, 0.03) 0.357
BOOST GTV MEDIAN 74.5(74.2-74.6, 0.1) 74.5(74.4-74.6, 0.04) 0.308
BOOST GTV D98% 73.5(72.9-74.2, 0.45) 73.2(72.5-73.8, 0.39) 0.075
BOOST GTV D2% 75.3(74.8-76, 0.38) 75.7(75.1-76.5, 0.46) 0.029
BOOST GTV D99 > 70.30Gy 73.5(72.7-74.2, 0.49) 73.1(72.2-73.3, 0.46) 0.068
BOOST PTV MAX 76.6(75.1-78.3, 0.9) 78.6(77–80.2, 0.9) 0.004
BOOST PTV MIN 66.4(63.3-69.5, 1.9) 67.1(65.2-69.5, 1.45) 0.168
BOOST PTV MEAN 74.2(73.6-74.5, 0.26) 74.1(73.7-74.4, 0.22) 0.056
BOOST PTV MEDIAN 74.4(73.8-74.6, 0.28) 74.3(74–74.6, 0.17) 0.350
BOOST PTV V95% (cc) 193(60.8-273, 65.1) 179(61.3-250, 55.9) 0.083
BOOST PTV D95% 71.9(71–72.9, 0.65) 71.3(70.2-72.2, 0.6) 0.023
BOOST PTV D2% 75.8(74.7-76.6, 0.53) 76.7(75.8-77.5, 0.48) 0.004
BOOST PTV D50% 74.4(73.8-74.6, 0.28) 74.3(74–74.6, 0.17) 0.350
BOOST PTV D99 > 70.30Gy 70.4(68–72, 1.08) 70.3(69.3-72, 0.78) 0.683
BOOST PTV D98 > 70.30Gy 71.1(69.9-72.4, 0.81) 70.7(69.7-72.4, 0.75) 0.185
RECTUM MEDIAN 36.4(19.2-43.9, 6.31) 37.1(19.2-49.1, 8.02) 0.351
RECTUM D98% 5.36(2.28-15.4, 4.3) 6.3(2.62-19.5, 4.78) 0.045
RECTUM D2% 66.1(50.8-72.6, 6.18) 66.8(44–75, 8.44) 0.100
RECTUM D60 < 40Gy 32.5(14.5-38, 6.39) 32.5(14.9-41.9, 7.6) 0.423
RECTUM D50 < 50Gy 36.4(19.2-43.9, 6.32) 37.1(19.2-49.1, 8) 0.415
RECTUM D40 < 64Gy 41(24–52.5, 6.9) 41.8(22.7-55.9, 8.68) 0.398
RT FEMUR MEDIAN 24(19.5-27.9, 2.23) 23.9(16.6-31.8, 4.28) 0.965
RT FEMUR D98% 3.07(1.73-6.82, 1.54) 2.86(1.18-5.45, 1.09) 0.625
RT FEMUR D2% 39.5(30.7-54.8, 7.3) 42.4(33–55, 5.96) 0.142
RT FEMUR D100 < 35Gy 1.96(1.17-3.33, 0.65) 2.1(1.28-3.96, 0.75) 0.126
RT FEMUR D60 < 45Gy 22.9(17.5-27.2, 2.59) 22.8(14.4-34.5, 5.6) 0.760
RT FEMUR D10 < 50Gy 31.8(27.1-39, 3.83) 36.8(29.9-47.4, 4.86) 0.041
LT FEMUR MEDIAN 24(19.2-28, 2.27) 20(16.2-24.6, 2.31) 0.009
LT FEMUR D98% 3.18(1.73-7.74, 1.87) 3.19(1.81-5.81, 1.35) 0.213
LT FEMUR D2% 35.5(29.6-46.9, 5.33) 37.4(30.1-45.5, 5.57) 0.505
LT FEMUR D100 < 35Gy 1.96(1.2-3.33, 0.62) 2.27(1.28-3.96, 0.91) 0.044
LT FEMUR D60 < 45Gy 23.1(17.9-27.1, 2.35) 18.5(14.8-24.1, 2.66) 0.008
LT FEMUR D10 < 50Gy 29.2(27–32.9, 2.13) 32.7(27.4-40.2, 4.7) 0.053
NON-RECTAL BOWEL MEDIAN 48.3(29.5-65.8, 11.6) 46.3(28.7-63.6, 12.1) 0.029
NON-RECTAL BOWEL D98% 15.6(7.5-26.9, 7.38) 13.5(6.63-31.9, 7.86) 0.045
NON-RECTAL BOWEL D2% 72.3(66.8-75.5, 3.13) 72.3(67–76.1, 3.37) 0.894
NON-RECTAL BOWEL D30 < 40Gy 59.2(33.6-71.7, 9.99) 58.4(37.2-68.8, 9.38) 0.351
NON-RECTAL BOWEL D0 < 45Gy 75.3(71.5-77.1, 1.53) 76.2(71.6-78.7, 2.19) 0.023
SMALL BOWEL MEDIAN 42.5(18.3-65.7, 14.8) 37.5(14.4-63.5, 16.6) 0.019
SMALL BOWEL D98% 16.7(5.81-33.6, 9.95) 12.7(5.88-25.7, 6.73) 0.008
SMALL BOWEL D2% 62(37–75.8, 16.4) 59.5(28–77.2, 20.4) 0.221
SMALL BOWEL D30 < 40Gy 50.9(23.3-70.5, 17.1) 47.2(17.3-67.2, 20.4) 0.076
SMALL BOWEL D0 < 45Gy 68.8(43.5-76.3, 13) 67.6(30–78.7, 17.5) 1.000
LARGE BOWEL MEDIAN 50.7(28.4-67, 11.1) 48.5(25.4-65, 12.2) 0.023
LARGE BOWEL D98% 15.1(6.46-26.9, 6.71) 13.6(6.23-31.9, 7.34) 0.068
LARGE BOWEL D2% 71.3(65.3-75.7, 3.29) 71.6(66.8-76.3, 3.19) 0.286
LARGE BOWEL D30 < 40Gy 61.7(45.5-73.3, 6.52) 60.2(37.8-72.9, 8.91) 0.168
LARGE BOWEL D0 < 45Gy 74.8(71.5-77.1, 1.52) 75.4(71.6-78.6, 2.3) 0.142
PLANNING TIME (MINS) 65.5(45–100, 19.7) 159(60–250, 54.3) 0.005
TOTAL MU 822(684–1047, 94.1) 419(359–464, 34.4) 0.004
PTV CONFORMITY INDEX (CI) 1.12(1.04-1.29, 0.07) 1.11(1.05-1.22, 0.05) 0.953
PTV BOOST CONFORMITY INDEX (CI) 1.14(0.99-1.48, 0.16) 1.06(0.97-1.23, 0.08) 0.068
PTV HOMOGENITY INDEX (HI) 0.196(0.18-0.22, 0.014) 0.2(0.08-0.24, 0.04) 0.258
PTV BOOST HOMOGENITY INDEX (HI) 0.06(0.03-0.08, 0.02) 0.081(0.05-0.1, 0.014) 0.009
EUD PTV 67.3(65.8-69, 1.24) 67.3 (66–69.1, 0.8) 0.965
TCP PTV 74%(71%-78%, 3%) 74%(71%-78%, 2%) 0.965
EUD PTV2 66(64.6-67.7, 1.21) 66(64.7-67.7, 0.78) 0.965
TCP PTV2 71%(67%-75%, 3%) 71%(68%-75%, 2%) 0.965
EUD rectum 54.1(37.1-61.6, 6.71) 55.6(38.7-64.4, 7.11) 0.011
EUD RTFEM 29.4(21.1-43.7, 6.42) 30.6(22.1- 42.9, 5.8) 0.505
EUD NRB 62.6(52.4-72.1, 5.05) 62.6(52.8-71, 4.95) 0.894
NTCP NRB 68%(13%-96%, 23%) 67%(14%-95%, 23% 0.722
EUD LFH 24.5(19.8-32.4, 3.81) 25.9(19.6-33.2, 4.89) 0.450