Table 5 SIB comparison using IMRT and VMAT
Variable | IMRT BOOST | VMAT BOOST | Â |
|---|---|---|---|
| Â | Mean(min-max, st dev) | Mean(min-max, st dev) | p-value |
CTV MAX | 76.1(75.1-77.2, 0.69) | 77.4(76–78.4, 0.66) | 0.004 |
CTV MIN | 63.2(61.7-66.3, 1.33) | 61.5(60.2-63.5, 1) | 0.011 |
CTV MEAN | 71.5(68.7- 74.3, 1.75) | 71.2(68.6-73.2, 1.43) | 0.398 |
CTV MEDIAN | 72.3(67–74.6, 2.88) | 71.9(66.9-74.1, 2.62) | 0.068 |
CTV D98% | 64.8(62.8-69.7, 2.2) | 64.4(62.9-68, 1.73) | 0.625 |
CTV D2% | 75.4(74.6-76.4-0.55) | 76(75–76.6, 0.48) | 0.007 |
CTV D99 > 60.8Gy | 64.5(62.5-69.1, 2.08) | 63.8(62.4-69.1, 1.85) | 0.044 |
PTV MAX | 76.7(75.1-78.3, 0.9) | 78.3(76.1-80.2, 1.15) | 0.006 |
PTV MIN | 55.1(47.3-57.4, 2.9) | 55.5(15.5-57.6, 1.93) | 0.476 |
PTV MEAN | 68.8(67.5-70.4, 1.2) | 68.8(67–70.4, 0.89) | 1.000 |
PTV MEDIAN | 67.9(65.5-71.6, 2.58) | 67.7(65.9. 70.1, 1.37) | 0.688 |
PTV V95% (cc) | 557(254–798, 171) | 552(267–804, 173) | 0.756 |
PTV D95% | 63.1(62.5-63.7, 0.46) | 62.9(62–63.9, 0.56) | 0.450 |
PTV D2% | 75.5(74.5-76.3, 0.49) | 75.9(73.4-76.8, 0.96) | 0.056 |
PTV D50% | 68.2(65.8-71.6, 2.45) | 67.7(65.9-70.1, 1.37) | 0.350 |
PTV D99 > 60.8Gy | 61.5(60.5-62.5, 0.58) | 61.9(60.3-70, 2.73) | 0.307 |
PTV D98 > 60.8Gy | 62.2(61.5-62.9, 0.47) | 61.9(61–63, 0.63) | 0.307 |
BOOST GTV MAX | 75.7(74.9-76.9, 0.57) | 76.6(75.4-77.6, 0.74) | 0.006 |
BOOST GTV MIN | 73.2(72.3-74, 0.52) | 72.9(71–77.2, 1.58) | 0.142 |
BOOST GTV MEAN | 74.5(74.4-74.5, 0.02) | 74.5(74.4-74.5, 0.03) | 0.357 |
BOOST GTV MEDIAN | 74.5(74.2-74.6, 0.1) | 74.5(74.4-74.6, 0.04) | 0.308 |
BOOST GTV D98% | 73.5(72.9-74.2, 0.45) | 73.2(72.5-73.8, 0.39) | 0.075 |
BOOST GTV D2% | 75.3(74.8-76, 0.38) | 75.7(75.1-76.5, 0.46) | 0.029 |
BOOST GTV D99 > 70.30Gy | 73.5(72.7-74.2, 0.49) | 73.1(72.2-73.3, 0.46) | 0.068 |
BOOST PTV MAX | 76.6(75.1-78.3, 0.9) | 78.6(77–80.2, 0.9) | 0.004 |
BOOST PTV MIN | 66.4(63.3-69.5, 1.9) | 67.1(65.2-69.5, 1.45) | 0.168 |
BOOST PTV MEAN | 74.2(73.6-74.5, 0.26) | 74.1(73.7-74.4, 0.22) | 0.056 |
BOOST PTV MEDIAN | 74.4(73.8-74.6, 0.28) | 74.3(74–74.6, 0.17) | 0.350 |
BOOST PTV V95% (cc) | 193(60.8-273, 65.1) | 179(61.3-250, 55.9) | 0.083 |
BOOST PTV D95% | 71.9(71–72.9, 0.65) | 71.3(70.2-72.2, 0.6) | 0.023 |
BOOST PTV D2% | 75.8(74.7-76.6, 0.53) | 76.7(75.8-77.5, 0.48) | 0.004 |
BOOST PTV D50% | 74.4(73.8-74.6, 0.28) | 74.3(74–74.6, 0.17) | 0.350 |
BOOST PTV D99 > 70.30Gy | 70.4(68–72, 1.08) | 70.3(69.3-72, 0.78) | 0.683 |
BOOST PTV D98 > 70.30Gy | 71.1(69.9-72.4, 0.81) | 70.7(69.7-72.4, 0.75) | 0.185 |
RECTUM MEDIAN | 36.4(19.2-43.9, 6.31) | 37.1(19.2-49.1, 8.02) | 0.351 |
RECTUM D98% | 5.36(2.28-15.4, 4.3) | 6.3(2.62-19.5, 4.78) | 0.045 |
RECTUM D2% | 66.1(50.8-72.6, 6.18) | 66.8(44–75, 8.44) | 0.100 |
RECTUM D60 < 40Gy | 32.5(14.5-38, 6.39) | 32.5(14.9-41.9, 7.6) | 0.423 |
RECTUM D50 < 50Gy | 36.4(19.2-43.9, 6.32) | 37.1(19.2-49.1, 8) | 0.415 |
RECTUM D40 < 64Gy | 41(24–52.5, 6.9) | 41.8(22.7-55.9, 8.68) | 0.398 |
RT FEMUR MEDIAN | 24(19.5-27.9, 2.23) | 23.9(16.6-31.8, 4.28) | 0.965 |
RT FEMUR D98% | 3.07(1.73-6.82, 1.54) | 2.86(1.18-5.45, 1.09) | 0.625 |
RT FEMUR D2% | 39.5(30.7-54.8, 7.3) | 42.4(33–55, 5.96) | 0.142 |
RT FEMUR D100 < 35Gy | 1.96(1.17-3.33, 0.65) | 2.1(1.28-3.96, 0.75) | 0.126 |
RT FEMUR D60 < 45Gy | 22.9(17.5-27.2, 2.59) | 22.8(14.4-34.5, 5.6) | 0.760 |
RT FEMUR D10 < 50Gy | 31.8(27.1-39, 3.83) | 36.8(29.9-47.4, 4.86) | 0.041 |
LT FEMUR MEDIAN | 24(19.2-28, 2.27) | 20(16.2-24.6, 2.31) | 0.009 |
LT FEMUR D98% | 3.18(1.73-7.74, 1.87) | 3.19(1.81-5.81, 1.35) | 0.213 |
LT FEMUR D2% | 35.5(29.6-46.9, 5.33) | 37.4(30.1-45.5, 5.57) | 0.505 |
LT FEMUR D100 < 35Gy | 1.96(1.2-3.33, 0.62) | 2.27(1.28-3.96, 0.91) | 0.044 |
LT FEMUR D60 < 45Gy | 23.1(17.9-27.1, 2.35) | 18.5(14.8-24.1, 2.66) | 0.008 |
LT FEMUR D10 < 50Gy | 29.2(27–32.9, 2.13) | 32.7(27.4-40.2, 4.7) | 0.053 |
NON-RECTAL BOWEL MEDIAN | 48.3(29.5-65.8, 11.6) | 46.3(28.7-63.6, 12.1) | 0.029 |
NON-RECTAL BOWEL D98% | 15.6(7.5-26.9, 7.38) | 13.5(6.63-31.9, 7.86) | 0.045 |
NON-RECTAL BOWEL D2% | 72.3(66.8-75.5, 3.13) | 72.3(67–76.1, 3.37) | 0.894 |
NON-RECTAL BOWEL D30 < 40Gy | 59.2(33.6-71.7, 9.99) | 58.4(37.2-68.8, 9.38) | 0.351 |
NON-RECTAL BOWEL D0 < 45Gy | 75.3(71.5-77.1, 1.53) | 76.2(71.6-78.7, 2.19) | 0.023 |
SMALL BOWEL MEDIAN | 42.5(18.3-65.7, 14.8) | 37.5(14.4-63.5, 16.6) | 0.019 |
SMALL BOWEL D98% | 16.7(5.81-33.6, 9.95) | 12.7(5.88-25.7, 6.73) | 0.008 |
SMALL BOWEL D2% | 62(37–75.8, 16.4) | 59.5(28–77.2, 20.4) | 0.221 |
SMALL BOWEL D30 < 40Gy | 50.9(23.3-70.5, 17.1) | 47.2(17.3-67.2, 20.4) | 0.076 |
SMALL BOWEL D0 < 45Gy | 68.8(43.5-76.3, 13) | 67.6(30–78.7, 17.5) | 1.000 |
LARGE BOWEL MEDIAN | 50.7(28.4-67, 11.1) | 48.5(25.4-65, 12.2) | 0.023 |
LARGE BOWEL D98% | 15.1(6.46-26.9, 6.71) | 13.6(6.23-31.9, 7.34) | 0.068 |
LARGE BOWEL D2% | 71.3(65.3-75.7, 3.29) | 71.6(66.8-76.3, 3.19) | 0.286 |
LARGE BOWEL D30 < 40Gy | 61.7(45.5-73.3, 6.52) | 60.2(37.8-72.9, 8.91) | 0.168 |
LARGE BOWEL D0 < 45Gy | 74.8(71.5-77.1, 1.52) | 75.4(71.6-78.6, 2.3) | 0.142 |
PLANNING TIME (MINS) | 65.5(45–100, 19.7) | 159(60–250, 54.3) | 0.005 |
TOTAL MU | 822(684–1047, 94.1) | 419(359–464, 34.4) | 0.004 |
PTV CONFORMITY INDEX (CI) | 1.12(1.04-1.29, 0.07) | 1.11(1.05-1.22, 0.05) | 0.953 |
PTV BOOST CONFORMITY INDEX (CI) | 1.14(0.99-1.48, 0.16) | 1.06(0.97-1.23, 0.08) | 0.068 |
PTV HOMOGENITY INDEX (HI) | 0.196(0.18-0.22, 0.014) | 0.2(0.08-0.24, 0.04) | 0.258 |
PTV BOOST HOMOGENITY INDEX (HI) | 0.06(0.03-0.08, 0.02) | 0.081(0.05-0.1, 0.014) | 0.009 |
EUD PTV | 67.3(65.8-69, 1.24) | 67.3 (66–69.1, 0.8) | 0.965 |
TCP PTV | 74%(71%-78%, 3%) | 74%(71%-78%, 2%) | 0.965 |
EUD PTV2 | 66(64.6-67.7, 1.21) | 66(64.7-67.7, 0.78) | 0.965 |
TCP PTV2 | 71%(67%-75%, 3%) | 71%(68%-75%, 2%) | 0.965 |
EUD rectum | 54.1(37.1-61.6, 6.71) | 55.6(38.7-64.4, 7.11) | 0.011 |
EUD RTFEM | 29.4(21.1-43.7, 6.42) | 30.6(22.1- 42.9, 5.8) | 0.505 |
EUD NRB | 62.6(52.4-72.1, 5.05) | 62.6(52.8-71, 4.95) | 0.894 |
NTCP NRB | 68%(13%-96%, 23%) | 67%(14%-95%, 23% | 0.722 |
EUD LFH | 24.5(19.8-32.4, 3.81) | 25.9(19.6-33.2, 4.89) | 0.450 |