Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index

Radiation Oncology

Table 5 Comparison of published data with regard to patterns of failure in patients with glioblastoma

Author	Year	Number	Treatment	Dose (Gy)	Margin (cm)	Recurrence sites
Author	Year	Number	Treatment	Dose (Gy)	Margin (cm)	Central	In-field	Marginal	Distant
Nakagawa [7]	1998	38	3DCRT + ACNU	60–80	0–2	90%^†			5%
				90	0–2	46%^††			8%
Lee [5]	1999	36	3DCRT	70–80	1.5	72%	17%	8%	3%
Chan [6]	2002	34	3DCRT	90	0.5	78%	13%	9%
Chang [3]	2007	48	3DCRT ± chemo^*	60	1	83%	6%	6%	4%
Brandes [16]	2009	95	3DCRT + TMZ	60	2–3	72%		6%	22%
Milano [15]	2010	54	3DCRT + TMZ	60	2–2.5	92%^§		15%	13%
Minniti [14]	2010	105	3DCRT + TMZ	60	1–2	79%	6%	6%	14%
McDonald [13]	2011	41	(IMRT or 3DCRT) ± TMZ	60	0.8	78%	15%	5%	2%
This study	2012	58	3DCRT ± (ACNU or TMZ)	60	1.5–2	69%	16%	12%	3%

*21/48 patients received adjuvant or concurrent chemotherapy (carmustine, procarbazine, and temozolomide).
†5% were subependymal recurrences (did not apply to our classification method of recurrence sites).
††46% were subependymal recurrences (did not apply to our classification method of recurrence sites).
§Insufficient data to apply to our classification method of recurrence sites.

ISSN: 1748-717X