Table 4 Results of univariate and multivariate analyses for OS and PFS in patients with glioblastoma or anaplastic astrocytoma
Variable | Test for favorable status | OS | PFS | |
|---|---|---|---|---|
Univariate analysis | P value | P value | ||
PS | 0,1 (n = 60) vs. 2,3, and 4 (n = 60) | <0.01 | <0.01 | |
Age | < 50 (n = 37) vs. ≧ 50 (n = 94) | 0.04 | 0.08 | |
Extent of resection | GTR/STR (n = 41) vs. PR/biopsy (n = 90) | 0.06 | 0.37 | |
Histological grade | AA (n = 26) vs. GB (n = 105) | 0.08 | 0.11 | |
MIB-1 LI | < 30 (n = 61) vs. ≧ 30 (n = 43) | 0.21 | 0.59 | |
BED or Radiation dose | ≤ 72 GyE (n = 77) vs. > 72 GyE (n = 54) | 0.29 | 0.53 | |
Gender | Male (n = 73) vs. Female (n = 58) | 0.73 | 0.54 | |
Chemotherapy (CT) | ACNU based (n = 55) vs. TMZ based (n = 56) | 0.91 | 0.45 | |
Multivariate analysis | ||||
PS | <0.01 | 0.01 | ||
Age | 0.04 | 0.07 | ||
Extent of resection | 0.04 | 0.30 | ||
MIB-1 LI | 0.07 | 0.12 | ||