Figure 1
From: Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity
Anchorage-independent growth levels of four kinds of MEF cells. After cells were exposed to 2 Gy of photons, permissive soft-agar assay was performed immediately to assess cell survival (Panel A) and 1 week later, non-permissive soft-agar assay were performed to assess neoplastic transformation (Panel B). Transformants were visually scored under a dissecting microscope. Data are from four independent experiments. * indicates the significant difference (p < 0.05) compared with ATMwt/BRCA1wt cells and ^ indicates the significant difference (p < 0.05) compared with ATMwt/BRCA1hz cells experienced the same treatment.