Neoadjuvant chemoradiation compared to neoadjuvant radiation alone and surgery alone for Stage II and III soft tissue sarcoma of the extremities

Table 3 Treatment outcomes with regard to overall survival, disease relapse (local, distant) and limb preservation by treatment method and disease presentation among 112 Stage II/III extremity soft-tissue sarcoma cases

Treatment/Disease Presentation	No. Pts	Survival Median (mos)	Overall Survival (%)			Local recurrence (%)			Distant Metastases (%)			Limb Preserved
			3-yr	5-yr	P	No (%)	3-yr	p	No. (%)	3-yr	P	No. (%)	P
SA	36	41.9	59	34		4 (11)	84		6 (17)	83		22 (61)
Primary	23	51.9	68	35	0.23	1 (4)	95	0.02	2 (9)	94	0.03	18 (78)	0.005
Recurrent	13	24.3	39	39		3 (23)	47		4 (31)	60		4 (31)
NR	37	74.4	67	57		4 (11)	88		11 (30)	68		1 (3)
Primary	31	74.3	67	61	0.75	2 (6)	94	0.006	9 (29)	71	0.63	29 (94)	0.54
Recurrent	6	37.4	67	*		2 (33)	56		2 (33)	50		6 (100)
NCR ^¶	39	*	73	59		4 (10)	85		13 (34)	58		34 (87)

SA, surgery alone; NR, neoadjuvant radiation alone; NCR - neoadjuvant chemoradiation; *, not reached; ¶, only 2 patients in NCR group had recurrent disease and have not developed local recurrence, distant metastases and were living at time of analysis.

ISSN: 1748-717X