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Table 3 Treatment outcomes with regard to overall survival, disease relapse (local, distant) and limb preservation by treatment method and disease presentation among 112 Stage II/III extremity soft-tissue sarcoma cases

From: Neoadjuvant chemoradiation compared to neoadjuvant radiation alone and surgery alone for Stage II and III soft tissue sarcoma of the extremities

Treatment/Disease
Presentation
No.
Pts
Survival
Median (mos)
Overall Survival (%) Local recurrence (%) Distant Metastases (%) Limb Preserved
    3-yr 5-yr P No (%) 3-yr p No. (%) 3-yr P No. (%) P
SA 36 41.9 59 34   4 (11) 84   6 (17) 83   22 (61)  
   Primary 23 51.9 68 35 0.23 1 (4) 95 0.02 2 (9) 94 0.03 18 (78) 0.005
   Recurrent 13 24.3 39 39   3 (23) 47   4 (31) 60   4 (31)  
NR 37 74.4 67 57   4 (11) 88   11 (30) 68   1 (3)  
   Primary 31 74.3 67 61 0.75 2 (6) 94 0.006 9 (29) 71 0.63 29 (94) 0.54
   Recurrent 6 37.4 67 *   2 (33) 56   2 (33) 50   6 (100)  
NCR 39 * 73 59   4 (10) 85   13 (34) 58   34 (87)  
  1. SA, surgery alone; NR, neoadjuvant radiation alone; NCR - neoadjuvant chemoradiation; *, not reached; ¶, only 2 patients in NCR group had recurrent disease and have not developed local recurrence, distant metastases and were living at time of analysis.