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Table 1 Characteristics of 112 high-grade, Stage II and III soft-tissue sarcoma cases

From: Neoadjuvant chemoradiation compared to neoadjuvant radiation alone and surgery alone for Stage II and III soft tissue sarcoma of the extremities

CHARACTERISTIC NCR NR SA P
All 39 37 36  
Sex/     
   Male 19 22 23 0.39
   Female 20 15 13  
Grade*     
   2 3 5 8 0.08
   3 17 7 10  
   4 16 21 13  
Age (years)     
   Median (range) 58 (17-88) 71 (32-93) 54.5 (18-86) 0.03
Anatomic site     
   Upper extremity 8 7 9 0.81
   Lower extremity 31 30 27  
Histology     
   Leiomyosarcoma 3 3 4  
   Liposarcoma 4 10 4  
   MFH 4 9 10 0.09
   Myxofibrosarcoma 12 8 2  
   Sarcoma NOS 5 2 1  
   Other 11a 5b 15c  
Tumor size (cm)d     
   Median (range) 10.6 (0.9-29.6) 8 (2.7-25) 4 (0.4-25) 0.01
   <5 cm 4 9 19 0.0002
   5-10 cm 14 13 6  
   >10 cm 20 11 6  
Primary disease 37 31 23 0.002
Relapsed disease 2 6 13  
  1. NCR, neoadjuvant chemoradiation; NR, neoadjuvant radiation alone; SA, surgery alone; MFH, malignant fibrous histiocytoma; NOS, not otherwise specified; cm, centimeters.
  2. *: Grade data missing on 3 NCR, 4 NR and 5 SA-treated patients.
  3. a: synovial sarcoma (n = 5); epithelioid sarcoma (n = 2); myxoid liposarcoma (n = 1); malignant peripheral nerve sheath tumor (n = 1); extraskeletal myxoid chondrosarcoma (n = 1); sclerosing epithelioid fibrosarcoma (n = 1).
  4. b: synovial sarcoma (n = 1); myxoid liposarcoma (n = 2); malignant peripheral nerve sheath tumor (n = 1); clear cell sarcoma of soft tissue (n = 1).
  5. c: synovial sarcoma (n = 4); epithelioid hemangiosarcoma (n = 1); epithelioid sarcoma (n = 1); myxoid liposarcoma (n = 1); malignant peripheral nerve sheath tumor (n = 2); mixed histologies (n = 1); clear cell sarcoma of soft tissue (n = 2); adult fibrosarcoma (n = 1); mesenchymal chondrosarcoma (n = 1); angiosarcoma (n = 1).
  6. d: Does not total 112 due to missing tumor size data for 10 patients.