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Table 1 Classification of seminomas according to UICC/AJCC and IGCCCG [7, 61]

From: Pure seminoma: A review and update

Clinical Stage

TNM (UICC/AJCC) Category

Blood tumor markers (S)

 

T

N

M

S

LDH

βHCG

(mIU/ml)

AFP

(ng/ml)

0

pTis

carcinoma in situ

N0

M0

-

-

-

-

IA

pT1

Limited to the testis and/or epididym, without lymphatic or vascular invasion, the tumor can infiltrate the tunica albuginea but not the tunical vaginalis

N0

M0

Any S level

Any LDH level

Any βHCG level

Norm.

IB

pT2

Limited to the testis and/or epididym, without lymphatic or vascular invasion, or spread through the tunica albuginea and invasion of the tunica vaginalis

N0

M0

Any S level

Any LDH level

Any βHCG level

Norm.

 

pT3

Infiltration of the spermatic cord

      
 

pT4

Infiltration of the scrotal wall

      

IIA

Any T stage

 

N1 (≤ 2 cm)

M0

Any S level

Any LDH level

Any βHCG level

Norm.

IIB

Any T stage

 

N1 (> 2 - 5 cm)

M0

Any S level

Any LDH level

Any βHCG level

Norm.

IIC

Any T stage

 

N1 (> 5 cm)

M0

Any S level

Any LDH level

Any βHCG level

Norm.

IIIA/B/C

Any T stage

 

Any N stage

M1a (non-regional nodes or lung metastasis)

Any S level

Any LDH level

Any βHCG level

Norm.

IIIC

Any T stage

 

Any N stage

M1b (other metastasis sites)

Any S level

Any LDH level

Any βHCG level

Norm.

IIIC

Mediastinal primary tumor

Any N stage

Any M stage

Any S level

Any LDH level

Any βHCG level

Norm.

  1. LDH: lactate deshydrogenase, βHCG: Beta Human chorionic gonadotrophin, AFP: alpha-fetoprotein, T: tumor, N: nodes, M: metastasis, S:blood marker, AJCC: American Joint Committee on Cancer, UICC: International Union Against Cancer, IGCCCG: International Germ Cell Cancer Collaborative Group