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Table 6 Influence of GI/GU toxicity on antitumor immune response.

From: The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques

Toxicity Variable Mean ± SD
(T)
Mean ± SD
(0)
p-value N
(T)
N
(0)
Acute GU
14th day
of 3D-CRT
% of T cells
(CD3+D56-)
68.41 ± 0.70 58.33 ± 8.99 0.047 26 11 (6)*
Acute GU
14th day
of 3D-CRT
Cytotoxicity 13.71 ± 5,21 6.54 ± 3.12 0.038 26 11 (6)
Late GU
15-20 days
after 3D-CRT
% of CTL
(CD3+CD8+)
15.99 ± 6.52 8.55 ± 2.26 0.002 13 24 (7)
Late GI
15-20 days
after 3D-CRT
Cytotoxicity 25.44 ± 4.96 13.82 ± 3.68 0.032 14 23 (2)
  1. For comparison of immune parameters between the group of patients suffering from any acute and late GU or GI toxicity (T), and the group of patients without toxicity side effects (0) after 3DCRT the t-test was applied.
  2. *Required sample size in each group for given standard deviation and difference of means between groups for α = 0.05 and power of the test β = 0.80 is given in the brackets