The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques

Table 6 Influence of GI/GU toxicity on antitumor immune response.

Toxicity	Variable	Mean ± SD (T)	Mean ± SD (0)	p-value	N (T)	N (0)
Acute GU 14^th day of 3D-CRT	% of T cells (CD3+D56-)	68.41 ± 0.70	58.33 ± 8.99	0.047	26	11 (6)*
Acute GU 14^th day of 3D-CRT	Cytotoxicity	13.71 ± 5,21	6.54 ± 3.12	0.038	26	11 (6)
Late GU 15-20 days after 3D-CRT	% of CTL (CD3+CD8+)	15.99 ± 6.52	8.55 ± 2.26	0.002	13	24 (7)
Late GI 15-20 days after 3D-CRT	Cytotoxicity	25.44 ± 4.96	13.82 ± 3.68	0.032	14	23 (2)

For comparison of immune parameters between the group of patients suffering from any acute and late GU or GI toxicity (T), and the group of patients without toxicity side effects (0) after 3DCRT the t-test was applied.
*Required sample size in each group for given standard deviation and difference of means between groups for α = 0.05 and power of the test β = 0.80 is given in the brackets

ISSN: 1748-717X