The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques

Table 5 Pearson's correlation coefficients of immune cells proportions with dosimetric parameters

14^th date of 3D CRT				15-20 days after completion of 3D CRT
Variable vs.	Variable	Pearson's correlation	p	Variable vs.	Variable	Pearson's correlation	p
T cells (CD3+CD56-)	D_min	-0.5869 (20)*	0.012	NK cells (CD3-CD56low)	Percentage of rectum receiving 70 Gy	-0.5436 (23)	0.024
	D_mean	-0.5068 (27)	0.032
	D_max of rectum	-0.4918 (29)	0.038
	D_max of urinary bladder	-0.6089 (18)	0.007
	Percentage of urinary bladder receiving 70 Gy	-0.4906 (29)	0.007
NKT cells (CD3+CD56+)	D_min of rectum	-0.5776 (20)	0.012	NKT cells (CD3+CD56+)	D_max of rectum	-0.6755 (14)	0.000
	D_mean of rectum	-0.7243 (12)	0.001		Percentage of rectum receiving 70 Gy	-0.4148 (42)	0.031
	Percentage of rectum receiving 40 Gy	-0.7363 (11)	0.000		D_max of urinary bladder	-0.6210 (17)	0.001
	Percentage of rectum receiving 50 Gy	-0.5613 (22)	0.015
NK cells (CD3-D56low)	D_min of rectum	0.3963 (47)	0.033	Activated B cells (CD19+CD20+ CD38+)	D_min of rectum	0.4582 (34)	0.016
	D_mean of rectum	0.3724 (53)	0.047		D_mean of rectum	0.4342 (38)	0.024
	Percentage of urinary bladder receiving 70 Gy	0.5152 (26)	0.004		Percentage of rectum receiving 50 Gy	0.4011 (46)	0.038
					Percentage of rectum receiving 60 Gy	0.5800 (20)	0.002
Terminally differentiated NK cells (CD3-CD56+)	D_min	0.4887 (30)	0.040	Terminally differentiated NK cells (CD3-CD56+)	D_max of rectum	-0.5549 (22)	0.000
	Percentage of rectum receiving 70 Gy	0.4835 (30)	0.042		D_max of urinary bladder	-0.4608 (34)	0.016
	Percentage of urinary bladder receiving 70 Gy	0.5226 (26)	0.026
	GI, GU toxicity	0.5166 (26)	0.028

*Required sample size for correlation coefficient for α = 0.05 and power of the test β = 0.80 is given in the brackets

ISSN: 1748-717X